Cusabio C-terminal 10xHis-tagged Recombinant

Introduction

Innovative Research’s human cystatin C purified 10X C-terminal histidine tag has been recombinantly produced in insect cell culture and purified. This is a frozen liquid buffered in 0.01 M sodium phosphate; 0.3M NaCl; pH 7.0, with a concentration of 1.0 mg/mL and greater than >95% purity as determined by SDS-PAGE analysis. This product can be used as a positive control for ELISA and western blot and for a variety of in vitro applications, including inhibition and more.

Cystatin C (CST3, cystatin-3, gamma-trace, neuroendocrine basic polypeptide, post-gamma-globulin, post-globulin G) is a small molecular weight peptide that is a potent inhibitor of many cysteine ​​proteinases. Due to its small size, it is freely filtered by the glomeruli and metabolized after tubular reabsorption. Serum cystatin C levels are a more accurate test of kidney function than serum creatinine levels. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease.

It also appears to play a role in brain disorders related to amyloid deposition, such as Creutzfeldt-Jakob disease and Alzheimer’s disease. Molecular Innovations’ human cystatin C is recombinantly produced in insect cell culture and purified by conventional affinity and metal chelate chromatography. Contains a 10X histidine tag at the C-terminus for purification. It functions as a single band and is greater than 95% pure by SDS-PAGE. Inhibits the activity of the cysteine ​​proteinase papain using the substrate Pyr-Phe-Leu-pNA.

Product name

C-terminal 10xHis-tagged recombinant

Full product name

N-terminal 10xHis-SUMO-tag and C-terminal Myc-tag

For research use only

For research use only. It should not be used in diagnostic procedures.

Host: E. coli

ISO Certification

Manufactured in an ISO 9001:2015 certified laboratory.

Other notes

Small volumes of N-terminal 10xHis-SUMO-tag and C-terminal Myc-tag Negative Control vials may occasionally become trapped in the product vial seal during shipping and storage. If necessary, briefly spin the vial in a tabletop centrifuge to dislodge any liquid in the vial cap. Certain products may require dry ice shipping and an additional dry ice fee may apply.

Precautions

All MyBioSource products are for scientific laboratory research purposes and not for diagnostic, therapeutic, prophylactic, or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Product purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe the intended use will not meet our acceptable guidelines.

Disclaimer

While every effort has been made to ensure the accuracy of the information provided in this datasheet, MyBioSource shall not be responsible for any omissions or errors contained in this document. MyBioSource reserves the right to make changes to this datasheet at any time without notice. It is the customer’s responsibility to report product performance issues to MyBioSource within 30 days of receiving the product.

Cusabio Neuroscience Recombinants

Abstract

Basic neuroscience Recombinants research employs antibodies as key reagents to label, capture, and modulate the function of proteins of interest. Antibodies are immunoglobulin proteins. Recombinant antibodies are immunoglobulin proteins whose nucleic acid coding regions, or fragments thereof, have been cloned into expression plasmids allowing unlimited production. Recombinant antibodies offer many advantages over conventional antibodies, including unequivocal identification and digital archiving through DNA sequencing, reliable expression, easy and reliable distribution as DNA sequences and plasmids, and the opportunity for numerous ways to engineer improve its usefulness.

Recombinant antibodies exist in many different forms, each of which offers potential advantages and disadvantages for neuroscience research applications. I provide an overview of recombinant antibodies and their development. Examples of their emerging use as valuable reagents in basic neuroscience research are also discussed. Many of these examples employ recombinant antibodies in innovative experimental approaches that cannot be carried out with conventional antibodies. 2020 Wiley Periodicals LLC.

Keywords:

brain; immunocytochemistry; immunohistochemistry; intrabody; a neuron.

Cusabio Cell Biology Recombinants

Abstract

Homologous recombination provides high-fidelity DNA repair in all domains of life. Live-cell fluorescence microscopy offers the opportunity to image individual recombination events in real-time, providing insights into the in vivo biochemistry of the proteins and DNA molecules involved, as well as the cellular organization of the homologous recombination process. . Here we review the cellular biological aspects of mitotic homologous recombination with a focus on Saccharomyces cerevisiae and mammalian cells, but we will also draw on findings from other experimental systems.

Key topics of this review include the stoichiometry and dynamics of recombination complexes in vivo, the choreography of assembly and disassembly of recombination proteins at sites of DNA damage, the mobilization of damaged DNA during homology search, and the functional compartmentalization of the nucleus with respect to The ability of homologous recomeniotic recombination is initiated by double-stranded DNA breaks Extensive base-pair interactions cannot occur between two intact DNA double helices.

Therefore, the DNA synapse that is critical for general recombination in meiosis can begin only after one DNA strand of one DNA helix has been exposed and its nucleotides have become available for pairing with another DNA helix. In the absence of direct experimental evidence, theoretical models were proposed based on the idea that a break needed to be made in only one of the two strands of a DNA helix to produce the exposed DNA strand required for DNA synapsis.

This break in the phosphodiester backbone was thought to allow one end of the nicked strand to separate from its associated base-paired strand, freeing it to form a short heteroduplex with an intact second DNA helix, thus beginning synapsis. Models of this type are reasonable in theory and have been described in textbooks for nearly 30 years.

In the early 1990s, sensitive biochemical techniques became available to determine the actual structure of recombination intermediates that are formed on yeast chromosomes at various stages of meiosis. These studies revealed that general recombination is initiated by a special endonuclease that simultaneously cuts both strands of the double helix, creating a complete break in the DNA molecule.

The 5′ ends at the break are then chewed up by an exonuclease, creating protruding single-stranded 3′ ends. It is these individual strands that seek out a homologous DNA helix to pair with, leading to the formation of a joint molecule between a maternal and paternal chromosomal pairing.

Recombinant ligand applications in molecular and cell biology

1. Cell proteomics

Proteome analysis relies on the availability of high-quality binding reagents. They are required for molecular analysis of specific target proteins and their spatiotemporal cellular abundance using standard detection methods such as microscopy and Western blot analysis. Furthermore, binder-mediated affinity purification in combination with systems biology techniques has contributed to a comprehensive understanding of cellular interactomes in development and disease.

Although such experiments have historically been performed with conventional antibodies, the use of recombinant binding reagents for proteomic applications is becoming increasingly popular, and international consortia have been set up with the long-term goal of covering the entire human proteome with renewable binders (Taussig et al., 2007; Colwill and Gräslund, 2011).

Biochemical and proteomic analyzes of crude samples include affinity-based purification or depletion of specific components using chromatography columns, however, requiring large amounts of affinity material. Therefore, expensive monoclonal and polyclonal antibodies are less attractive for purifying or depleting endogenous proteins, while inexpensive immobilized metal affinity chromatography (IMAC) systems, such as the Ni-NTA (nitrilotriacetic acid)/His- tag, are widely used but also restricted to artificially tagged proteins. Consequently, recombinant binders that can be produced cheaply in large quantities offer valuable alternatives for immunoaffinity chromatography of biological samples.

2. Confirmation and PTM sensors

As discussed in the structural biology section, affinity reagents can detect and stabilize specific conformational states of proteins. Consequently, reformulating such binders as intracellular biosensors potentially allows spatiotemporal analysis of specific conformational changes and their biological implications in living Cell Biology Recombinants. Such an application was shown for a nanobody that binds to the activated conformation of the β2-adrenoceptor (Rasmussen et al., 2011a).

Fusion of this binder with GFP informs the subcellular localization of activated β2-adrenoceptor and leads to the identification of endosomal membranes as initiation sites for acute G protein-coupled receptor signalling, previously thought to occur exclusively at the membrane. plasma (Irannejad et al., 2012). al., 2013). Similarly, a DARPin that recognizes the activated phosphorylated conformation of the extracellular signal-regulated kinase (ERK; Kummer et al., 2012) was conjugated with a solvatochromic merocyanine to quantitatively report active localization of pERK in living cells in the absence and presence of an inhibitor of the upstream regulatory kinase MEK1/2 (Kummer et al., 2013).

Interestingly, this DARPin recognizes a conformational change within the activation cycle that is dependent on activation and thus indirectly informs the main modification, ERK phosphorylation. Like conventional antibodies, recombinant binders can be raised against PTMs and non-protein epitopes. Therefore, the application of recombinant binders in living cells paves the way towards dynamic PTM analysis, as demonstrated with a GFP-tagged scFv that specifically recognizes histone acetylation (H3K9ac) and is used for dynamic chromatin monitoring. epigenetics in living cells and living animals. modulation (Sato et al., 2013).

3. PPI

Screening for PPIs is often done in vitro or in yeast. In living cells, PPIs can be tested with FRET, which is technically demanding, or with protein fragment complementation assays, which do not report in real-time and are irreversible. In contrast, the newly developed fluorescent-3-hybrid (F3H) assay is based on recombinant immune recruitment and allows dynamic and reversible monitoring of PPIs in living mammalian cells with a simple optical readout GFP fusions with proteins of interest (bait) were recruited into discrete subcellular structures, such as artificial Laco DNA arrays, by fusing GBP with the Lac repressor.

In addition, major natural satellite repeats, the nuclear periphery, and cytoplasmic structures such as centrosomes can be used as anchor points. The enrichment of red fluorescent prey proteins at the respective docking sites indicates a specific interaction. The nanobody-based F3H assay is also suitable for drug discovery, as small molecule compounds or peptides that prevent or disrupt PPIs can be identified. With this F3H assay, for example, disruption of p53-HDM2 interaction by potential anticancer drugs such as Nutlin-3 was monitored in live cells, providing direct information on dose-response, kinetics, and bioavailability ( Herce et al., 2013).

Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation

Phosphorylation of the translation initiation issue eIF2α is a fast and very important response to many varieties of stress, together with protein-misfolding stress in the endoplasmic reticulum (ER stress). It is believed to trigger a basic discount in protein synthesis whereas enabling translation of few transcripts. Such a discount of protein synthesis comes with the risk of depleting important proteins, a danger regarded as mitigated by its transient nature. Here, we discover that translation attenuation shouldn’t be uniform, with cytosolic and mitochondrial ribosomal subunits being prominently downregulated.

Translation attenuation of these targets persists after translation restoration. Surprisingly, this happens with no measurable lower in ribosomal proteins. Explaining this conundrum, translation attenuation preferentially targets long-lived proteins, a discovering not solely demonstrated by ribosomal proteins but additionally noticed at a worldwide stage. This exhibits that protein stability buffers the price of translational attenuation, establishing an evolutionary precept of mobile robustness. Somatic mutations in the RAS genes are frequent in human tumors, particularly in pancreatic, colorectal, and non-small-cell lung cancers.

Such mutations usually lower the capability of Ras to hydrolyze GTP, sustaining the protein in a constitutively energetic GTP-bound kind that drives uncontrolled cell proliferation. Efforts to develop medicine that focus on Ras oncoproteins have been unsuccessful. Recent rising knowledge recommend that Ras regulation is extra advanced than the scientific neighborhood has believed for many years. In this overview, we summarize advances in the “textbook” view of Ras activation. We additionally focus on a novel sort of Ras regulation that entails direct phosphorylation and dephosphorylation of Ras tyrosine residues. The discovery that pharmacological inhibition of the tyrosine phosphoprotein phosphatase SHP2 maintains mutant Ras in an inactive state means that SHP2 could possibly be a novel drug goal for the remedy of Ras-driven human cancers.

Temporal quantitative proteomics of mGluR-induced protein translation and phosphorylation in neurons

At neuronal synapses, activation of group I metabotropic glutamate receptors (mGluR1/5) triggers a kind of long-term despair (mGluR-LTD) that depends on new protein synthesis and the internalization of AMPA-type glutamate receptors. Dysregulation of these processes has been implicated in the growth of psychological problems akin to autism spectrum problems and subsequently advantage a greater understanding on a molecular stage. Here, to review mGluR-induced signaling pathways, we built-in quantitative phosphoproteomics with the analyses of newly synthesized proteins through bio-orthogonal amino acids (azidohomoalanine) in a pulsed labeling technique in cultured hippocampal neurons stimulated with DHPG, a particular agonist for group I mGluRs.

We recognized a number of kinases with necessary roles in DHPG-induced mGluR activation, which we confirmed utilizing small molecule kinase inhibitors. Furthermore, adjustments in the AMPA receptor endocytosis pathway in each protein synthesis and protein phosphorylation have been recognized, whereby Intersectin-1 was validated as a novel participant on this pathway. This examine revealed a number of new insights into the molecular pathways downstream of group I mGluR activation in hippocampal neurons, and supplies a wealthy useful resource for additional analyses. The intracellular parasite Toxoplasma gondii resides inside a membrane-bound parasitophorous vacuole (PV) and secretes an array of proteins to determine this replicative area of interest.

It has been proven beforehand that Toxoplasma secretes kinases and that quite a few proteins are phosphorylated after secretion. Here, we assess the position of the phosphorylation of strand-forming protein 1 (SFP1) and the associated protein GRA29, two secreted proteins with unknown perform. We present that each proteins kind stranded constructions in the PV which are unbiased of the beforehand described intravacuolar community or actin. SFP1 and GRA29 can every kind these constructions independently of different Toxoplasma secreted proteins, though GRA29 seems to control SFP1 strands. We present that an unstructured area at the C termini of SFP1 and GRA29 is required for the formation of strands and that mimicking the phosphorylation of this area of SFP1 negatively regulates strand growth.

When tachyzoites convert to chronic-stage bradyzoites, each proteins present a dispersed localization all through the cyst matrix. Many secreted proteins are reported to dynamically redistribute as the cyst varieties, and secreted kinases are recognized to play a task in cyst formation. Using quantitative phosphoproteome and proteome analyses evaluating tachyzoite and early bradyzoite phases, we reveal widespread differential phosphorylation of secreted proteins. While we discovered no direct proof for phosphorylation taking part in a dominant position for SFP1/GRA29 redistribution in the cyst, these knowledge help a mannequin during which secreted kinases and phosphatases contribute to the regulation of secreted proteins throughout stage conversion.

Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation

Greenbug (Schizaphis graminum) herbivory considerably impacts protein and phosphorylation abundance in switchgrass (Panicum virgatum)

Switchgrass (Panicum virgatum L.) is a crucial crop for biofuel manufacturing nevertheless it additionally serves as host for greenbugs (Schizaphis graminum Rondani; GB). Although transcriptomic research have been achieved to deduce the molecular mechanisms of plant protection in opposition to GB, little is understood about the impact of GB infestation on the switchgrass protein expression and phosphorylation regulation.

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RQ5298 100ul
EUR 356.15
Description: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins such as maltotriose. [UniProt]

Maltose Binding Protein Antibody / malE / MBP tag

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EUR 356.15
Description: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins such as maltotriose. [UniProt]

Maltose Binding Protein Antibody / malE / MBP tag

RQ5300 100ul
EUR 356.15
Description: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins such as maltotriose. [UniProt]

Maltose Binding Protein Antibody / malE / MBP tag

V8292-100UG 100 ug
EUR 424.15
Description: Plasmid vectors for the expression of coding regions of eukaryotic genes in bacterial, insect and mammalian hosts are in common usage; such expression vectors frequently encode hybrid fusion proteins consisting in part of prokaryotic and in part, eukaryotic specified proteins. One such system utilizes maltose binding protein (MBP), the 370 amino acid product of the E. coli mal E gene. Plasmid vectors have been constructed utilizing the MBP domain that allow the synthesis of high levels of MBP-fusion proteins that can be Purified in a one step procedure by affinity chromatography crosslinked amylose resin. Once bound to amylose, the MBP protein can then be separated from the target protein by cleavage by coagulation factor Xa at a specific four residue site. Alternatively, the intact fusion protein can be specifically eluted from the resin by the addition of excess free maltose. Subsequent to elution, MBP fusion protein can be visualized either by Western Blot Analysis or immunoprecipitation using antibodies specific for the MBP-tag. Expression systems utilizing the MBP fusion tag include pCG-806fx and pMal vectors.

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V8292-20UG 20 ug
EUR 186.15
Description: Plasmid vectors for the expression of coding regions of eukaryotic genes in bacterial, insect and mammalian hosts are in common usage; such expression vectors frequently encode hybrid fusion proteins consisting in part of prokaryotic and in part, eukaryotic specified proteins. One such system utilizes maltose binding protein (MBP), the 370 amino acid product of the E. coli mal E gene. Plasmid vectors have been constructed utilizing the MBP domain that allow the synthesis of high levels of MBP-fusion proteins that can be Purified in a one step procedure by affinity chromatography crosslinked amylose resin. Once bound to amylose, the MBP protein can then be separated from the target protein by cleavage by coagulation factor Xa at a specific four residue site. Alternatively, the intact fusion protein can be specifically eluted from the resin by the addition of excess free maltose. Subsequent to elution, MBP fusion protein can be visualized either by Western Blot Analysis or immunoprecipitation using antibodies specific for the MBP-tag. Expression systems utilizing the MBP fusion tag include pCG-806fx and pMal vectors.

Maltose Binding Protein Antibody / malE / MBP tag

V8292SAF-100UG 100 ug
EUR 424.15
Description: Plasmid vectors for the expression of coding regions of eukaryotic genes in bacterial, insect and mammalian hosts are in common usage; such expression vectors frequently encode hybrid fusion proteins consisting in part of prokaryotic and in part, eukaryotic specified proteins. One such system utilizes maltose binding protein (MBP), the 370 amino acid product of the E. coli mal E gene. Plasmid vectors have been constructed utilizing the MBP domain that allow the synthesis of high levels of MBP-fusion proteins that can be Purified in a one step procedure by affinity chromatography crosslinked amylose resin. Once bound to amylose, the MBP protein can then be separated from the target protein by cleavage by coagulation factor Xa at a specific four residue site. Alternatively, the intact fusion protein can be specifically eluted from the resin by the addition of excess free maltose. Subsequent to elution, MBP fusion protein can be visualized either by Western Blot Analysis or immunoprecipitation using antibodies specific for the MBP-tag. Expression systems utilizing the MBP fusion tag include pCG-806fx and pMal vectors.

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MBP Maltose Binding Protein (27-396) E.coli Recombinant Protein

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EUR 380.4
Description: Recombinant E.Coli MBP produced in E.Coli is a single, non-glycosylated polypeptide chain containing 371 amino acids (27-396 a.a) and having a molecular mass of 40.8kDa. ;MBP protein was purified by proprietary chromatographic techniques.

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 287.5

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody

abx345735-100g 100 µg Ask for price

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody

abx345735-20g 20 µg
EUR 250

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody

abx345735-50g 50 µg
EUR 350

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody

abx345739-100g 100 µg Ask for price

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody

abx345739-20g 20 µg
EUR 250

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody

abx345739-50g 50 µg
EUR 350

Escherichia coli Maltose-binding periplasmic protein (malE)

1-CSB-EP360183ENV
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Description: Recombinant Escherichia coli Maltose-binding periplasmic protein(malE) expressed in E.coli

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody (HRP)

abx345736-100g 100 µg Ask for price

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody (HRP)

abx345736-20g 20 µg
EUR 250

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody (HRP)

abx345736-50g 50 µg
EUR 350

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody (FITC)

abx345737-100g 100 µg Ask for price

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody (FITC)

abx345737-20g 20 µg
EUR 250

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody (FITC)

abx345737-50g 50 µg
EUR 350

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody (Biotin)

abx345738-100g 100 µg Ask for price

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody (Biotin)

abx345738-20g 20 µg
EUR 250

Maltose/maltodextrin-binding periplasmic protein (malE) Antibody (Biotin)

abx345738-50g 50 µg
EUR 350

Maltose

HY-N2024 100mg
EUR 129.6

Maltose

T0584-10mg 10mg Ask for price
Description: Maltose

Maltose

T0584-1g 1g Ask for price
Description: Maltose

Maltose

T0584-1mg 1mg Ask for price
Description: Maltose

Maltose

T0584-50mg 50mg Ask for price
Description: Maltose

Maltose

T0584-5mg 5mg Ask for price
Description: Maltose

Recombinant Escherichia coli Maltose/maltodextrin-binding periplasmic protein (malE)

CSB-EP360183ENV 3325 mg Ask for price

Recombinant Escherichia coli Maltose/maltodextrin-binding periplasmic protein (malE)

RPC25825-100ug 100ug
EUR 721.6

Recombinant Escherichia coli Maltose/maltodextrin-binding periplasmic protein (malE)

RPC25825-1mg 1mg
EUR 2884.7

Recombinant Escherichia coli Maltose/maltodextrin-binding periplasmic protein (malE)

RPC25825-20ug 20ug
EUR 448.1

Maltose Ma

DD005-1VL 1 unit
EUR 1.89
Description: Maltose Ma

Maltose - EACH

LCS-4188 EACH
EUR 279.45

Maltose 500gm - EACH

216830 EACH
EUR 174.15

Maltose Monohydrate

11661-52 25G
EUR 42

Maltose Monohydrate

21115-02 25G
EUR 9.45

The world response of the switchgrass cultivar Summer proteome and phosphoproteome was monitored by label-free proteomics shotgun in GB-infested and uninfested management vegetation at 10 days submit infestation. Peptides matching a complete of 3,594 proteins have been recognized and 429 have been differentially expressed proteins in GB-infested vegetation relative to uninfested management vegetation. Among these, 291 and 138 have been up and downregulated by GB infestation, respectively. Phosphoproteome evaluation recognized 310 differentially phosphorylated proteins (DP) from 350 phosphopeptides with a complete of 399 phosphorylated websites.

Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

An in depth relationship has been reported to exist between cadherin-mediated cell-cell adhesion and integrin-mediated cell mobility, and protein tyrosine phosphatase 1B (PTP1B) could also be concerned in sustaining this homeostasis. The steady residence of mesenchymal stem cells (MSCs) and endothelial cells (ECs) of their niches is carefully associated to the regulation of PTP1B. However, the precise position of the departure of MSCs and ECs from their niches throughout bone regeneration is essentially unknown. Here, we present that the phosphorylation state of PTP1B tyrosine-152 (Y152) performs a central position in initiating the departure of these cells from their niches and their subsequent recruitment to bone defects.

Based on our earlier design of a PTP1B Y152 region-mimicking peptide (152RM) that considerably inhibits the phosphorylation of PTP1B Y152, additional investigations revealed that 152RM enhanced cell migration partly through integrin αvβ3 and promoted MSCs osteogenic differentiation partly by inhibiting ATF3. Moreover, 152RM induced kind H vessels formation by activating Notch signaling. Demineralized bone matrix (DBM) scaffolds had been fabricated with mesoporous silica nanoparticles (MSNs), and 152RM was then loaded onto them by electrostatic adsorption. The DBM-MSN/152RM scaffolds had been demonstrated to induce bone formation and sort H vessels growth in vivo.

Elevated expression of β4-galactosyltransferase (β4GalT) Three is correlated with poor medical consequence of neuroblastoma sufferers. Our current examine has revealed that the transcription of the β4GalT3 gene is activated by Specificity protein (Sp) Three in SH-SY5Y human neuroblastoma cell line. Here we report the organic significance of the SpThree phosphorylation within the transcriptional activation of the β4GalT3 gene. The therapy of SH-SY5Y cells with 10% fetal bovine serum (FBS) elevated the mitogen-activated protein kinase (MAPK) signaling and the promoter exercise of the β4GalT3 gene.

Meanwhile, the therapy with U0126, an inhibitor for MAPK kinase, decreased the MAPK signaling and the promoter exercise. These findings point out that the transcriptional activation of the β4GalT3 gene is mediated by the MAPK signaling. In SH-SY5Y cells cultured within the medium containing 10% FBS, the serine (Ser) residues in SpThree had been phosphorylated. In conclusion, our knowledge reveal that 152RM contributes to bone formation by coupling osteogenesis with angiogenesis, which can provide a possible therapeutic technique for bone defects.

Quantitative Phosphoproteomics Reveals the Role of Protein Arginine Phosphorylation within the Bacterial Stress Response

Arginine phosphorylation is an rising protein modification implicated within the common stress response of Gram-positive micro organism. The modification is mediated by the arginine kinase McsB, which phosphorylates and inactivates the warmth shock repressor CtsR. In this examine, we developed a mass spectrometric method accounting for the peculiar chemical properties of phosphoarginine. The improved methodology was used to investigate the dynamic adjustments within the Bacillus subtilis arginine phosphoproteome in response to completely different stress conditions.

Quantitative evaluation confirmed {that a} B. subtilis mutant missing the YwlE arginine phosphatase accrued a strikingly massive quantity of arginine phosphorylations (217 websites in 134 proteins), nevertheless solely a minor fraction of these websites was more and more modified throughout warmth shock or oxidative stress. The most important targets of McsB-mediated arginine phosphorylation comprise central elements of the stress response system together with the CtsR and HrcA warmth shock repressors, in addition to main elements of the protein high quality management system such because the ClpCP protease and the GroEL chaperonine.

These findings spotlight the impression of arginine phosphorylation in orchestrating the bacterial stress response. In vegetation, SNF1-related protein kinase 1 (SnRK1) senses nutrient and power standing and transduces this info into applicable responses. Oxidative Stress 3 (OXS3) and members of the family share a extremely conserved putative N-acetyltransferase catalytic area (ACD). Here, we describe that the ACD comprises two candidate SnRK1 recognition motifs and that SnRK1 can work together with most of the OXS3 household proteins. In vitro, SnRK1.1 can phosphorylate OXS3, OXS3b and O3L4, and in vivo promote the translocation of OXS3, OXS3b and O3L6 from the nucleus to the cytoplasm.

Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

Arg-Gly-Asp-modified elastin-like polypeptide regulates cell proliferation and cell cycle proteins through the phosphorylation of Erk and Akt in pancreatic β-cell

Enhancement of β-cell proliferation performs an vital position in sustaining β-cell mass and performance, and in enhancing pancreatic β-cell survival earlier than transplantation. Extracellular matrix (ECM) elements enhance the adhesion and proliferation of β-cells, and the RGD-modified elastin-like polypeptide (RGD-ELP, REP) has been described as a bioactive matrix. In this examine, we investigated whether or not REP may improve β-cell adhesion and proliferation and elucidated the signaling pathways concerned.
We investigated the impact of REP on cell adhesion, proliferation and insulin secretion through assays utilizing Rin-m and rat islets. Crystal violet, CCK-8, and BrdU assay, FACS, western blot, actual time q-PCR analyses and insulin ELISA had been examined. To clarify the related mechanisms, phosphorylation of Akt and extracellular signal-regulated kinase (Erk) had been measured.REP extra elevated the adhesion, proliferation and survival of Rin-m cells in comparison with elastin-like poly peptide (ELP) with out RGD-motif. The enhancement of β-cell proliferation by REP was related with elevated cyclin D1, cyclin D2 and cdk6, and decreased p27 ranges.

Capsid protein VP1 Antibody

abx317823-50g 50 µg
EUR 250

Rotavirus Capsid Protein Antibody

GWB-598577 0.1 mg Ask for price

Rotavirus Capsid Protein Antibody

abx415701-01mg 0.1 mg
EUR 526.8

Astrovirus Capsid Protein Antibody

GWB-T00714 1 mg Ask for price

Major capsid protein L1 antibody

70R-15488 100 ug
EUR 303
Description: Rabbit polyclonal Major capsid protein L1 antibody

Capsid protein VP1 Antibody (HRP)

20-abx317824
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  • 100 ug
  • 1 mg
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  • 20 ug
  • 50 ug

Capsid protein VP1 Antibody (HRP)

abx317824-100g 100 µg
EUR 362.5

Capsid protein VP1 Antibody (HRP)

abx317824-20g 20 µg
EUR 162.5

Capsid protein VP1 Antibody (HRP)

abx317824-50g 50 µg
EUR 250

Capsid protein VP1 Antibody (FITC)

20-abx317825
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  • 100 ug
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  • 20 ug
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Capsid protein VP1 Antibody (FITC)

abx317825-100g 100 µg
EUR 362.5

Capsid protein VP1 Antibody (FITC)

abx317825-20g 20 µg
EUR 162.5

Capsid protein VP1 Antibody (FITC)

abx317825-50g 50 µg
EUR 250

Norovirus GI Capsid Protein Antibody

abx024099-1mg 1 mg
EUR 1128

Norovirus GI Capsid Protein Antibody

abx024100-1mg 1 mg
EUR 1128

Norovirus GI Capsid Protein Antibody

abx024101-1mg 1 mg
EUR 1128

Norovirus GI Capsid Protein Antibody

abx024102-1mg 1 mg
EUR 1128

Norovirus GI Capsid Protein Antibody

abx024103-1mg 1 mg
EUR 1128

Norovirus GI Capsid Protein Antibody

abx024099-400l 400 µl Ask for price

Norovirus GI Capsid Protein Antibody

abx024099-80l 80 µl
EUR 1200

Norovirus GI Capsid Protein Antibody

abx024100-400l 400 µl Ask for price

Norovirus GI Capsid Protein Antibody

abx024100-80l 80 µl
EUR 1200

Norovirus GI Capsid Protein Antibody

abx024101-400l 400 µl Ask for price

Norovirus GI Capsid Protein Antibody

abx024101-80l 80 µl
EUR 1200

Norovirus GI Capsid Protein Antibody

abx024102-200l 200 µl Ask for price

Norovirus GI Capsid Protein Antibody

abx024102-50l 50 µl
EUR 1200

Norovirus GI Capsid Protein Antibody

abx024103-400l 400 µl Ask for price

Norovirus GI Capsid Protein Antibody

abx024103-80l 80 µl
EUR 1200

Outer capsid protein VP4 Antibody

20-abx319784
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Outer capsid protein VP4 Antibody

1-CSB-PA320838LA01ROH
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  • 100ug
  • 50ug
Description: A polyclonal antibody against Outer capsid protein VP4. Recognizes Outer capsid protein VP4 from Rotavirus A. This antibody is Unconjugated. Tested in the following application: ELISA

Minor capsid protein VP2 Antibody

1-CSB-PA355948LA01JAK
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  • 100ug
  • 50ug
Description: A polyclonal antibody against Minor capsid protein VP2. Recognizes Minor capsid protein VP2 from JC polyomavirus. This antibody is Unconjugated. Tested in the following application: ELISA

Outer capsid protein VP4 Antibody

abx319784-100l 100 µl
EUR 250

Outer capsid protein VP4 Antibody

abx319784-50l 50 µl
EUR 162.5

Norovirus GII Capsid Protein Antibody

abx024104-1mg 1 mg
EUR 1128

Norovirus GII Capsid Protein Antibody

abx024105-1mg 1 mg
EUR 1128

Norovirus GII Capsid Protein Antibody

abx024106-1mg 1 mg
EUR 1128

Norovirus GII Capsid Protein Antibody

abx024107-1mg 1 mg
EUR 1128

Norovirus GII Capsid Protein Antibody

abx024108-1mg 1 mg
EUR 1128

Rubella Virus Capsid Protein Antibody

abx022208-1mg 1 mg
EUR 610.8

Rubella Virus Capsid Protein Antibody

GWB-751C39 0.2 mg Ask for price

Norovirus GII Capsid Protein Antibody

abx024104-400l 400 µl Ask for price

Norovirus GII Capsid Protein Antibody

abx024104-80l 80 µl
EUR 1200

Norovirus GII Capsid Protein Antibody

abx024105-400l 400 µl Ask for price

Norovirus GII Capsid Protein Antibody

abx024105-80l 80 µl
EUR 1200

Norovirus GII Capsid Protein Antibody

abx024106-400l 400 µl Ask for price

Norovirus GII Capsid Protein Antibody

abx024106-80l 80 µl
EUR 1200

Norovirus GII Capsid Protein Antibody

abx024107-400l 400 µl Ask for price

Norovirus GII Capsid Protein Antibody

abx024107-80l 80 µl
EUR 1200

Norovirus GII Capsid Protein Antibody

abx024108-400l 400 µl Ask for price

Norovirus GII Capsid Protein Antibody

abx024108-80l 80 µl
EUR 1200

Rubella Virus Capsid Protein Antibody

abx022208-400l 400 µl Ask for price

Rubella Virus Capsid Protein Antibody

abx022208-80l 80 µl
EUR 550

Capsid protein VP1 Antibody (Biotin)

20-abx317826
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
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Capsid protein VP1 Antibody (Biotin)

abx317826-100g 100 µg
EUR 362.5

Capsid protein VP1 Antibody (Biotin)

abx317826-20g 20 µg
EUR 162.5

Capsid protein VP1 Antibody (Biotin)

abx317826-50g 50 µg
EUR 250

Major Capsid Protein L1 (L1) Antibody

20-abx317807
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  • 100 ug
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Minor Capsid Protein L2 (L2) Antibody

20-abx317811
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  • 100 ug
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  • 200 ug
  • 20 ug
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Minor Capsid Protein L2 (L2) Antibody

20-abx317815
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  • 100 ug
  • 1 mg
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  • 20 ug
  • 50 ug

Minor Capsid Protein L2 (L2) Antibody

abx317811-100g 100 µg
EUR 362.5

Minor Capsid Protein L2 (L2) Antibody

abx317811-20g 20 µg
EUR 162.5

Minor Capsid Protein L2 (L2) Antibody

abx317811-50g 50 µg
EUR 250

Minor Capsid Protein L2 (L2) Antibody

abx317815-100g 100 µg
EUR 362.5

Minor Capsid Protein L2 (L2) Antibody

abx317815-20g 20 µg
EUR 162.5

Minor Capsid Protein L2 (L2) Antibody

abx317815-50g 50 µg
EUR 250

OASA04290-100UG - CAPSID Protein Antibody

OASA04290-100UG 0.1mg
EUR 309

Major capsid protein L1 antibody (HRP)

60R-2281 100 ug
EUR 302
Description: Rabbit polyclonal Major capsid protein L1 antibody (HRP)

Capsid Protein VP2 Polyclonal Antibody

A57197
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  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

Major capsid protein L1 antibody (FITC)

60R-2282 100 ug
EUR 302
Description: Rabbit polyclonal Major capsid protein L1 antibody (FITC)

HPV18 Major capsid protein L1 Antibody

20-abx110595
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  • 100 ug
  • 1 mg
  • 200 ug
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  • 50 ug

HIV-1 (Capsid protein p24), Antibody

GWB-89F8F0 0.2 mg Ask for price

HIV-2 Capsid Protein p24, Antibody

GWB-6FC62E 0.1 mg Ask for price

Intermediate capsid protein VP6 Antibody

1-CSB-PA321618LA01PGK
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  • 100ug
  • 50ug
Description: A polyclonal antibody against Intermediate capsid protein VP6. Recognizes Intermediate capsid protein VP6 from Rotavirus A. This antibody is Unconjugated. Tested in the following application: ELISA

Intermediate capsid protein VP6 Antibody

1-CSB-PA541481LA01ROG
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  • 100ug
  • 50ug
Description: A polyclonal antibody against Intermediate capsid protein VP6. Recognizes Intermediate capsid protein VP6 from Rotavirus A. This antibody is Unconjugated. Tested in the following application: ELISA

Intermediate capsid protein VP6 Antibody

1-CSB-PA542165LA01ROH
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  • 100ug
  • 50ug
Description: A polyclonal antibody against Intermediate capsid protein VP6. Recognizes Intermediate capsid protein VP6 from Rotavirus A. This antibody is Unconjugated. Tested in the following application: ELISA

Major capsid protein L1 antibody (biotin)

60R-2283 100 ug
EUR 302
Description: Rabbit polyclonal Major capsid protein L1 antibody (biotin)

Outer capsid protein VP4 Antibody (HRP)

20-abx319785
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Outer capsid protein VP4 Antibody (HRP)

abx319785-100l 100 µl
EUR 250

Outer capsid protein VP4 Antibody (HRP)

abx319785-50l 50 µl
EUR 162.5

Outer capsid protein VP4 Antibody (FITC)

20-abx319786
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Outer capsid protein VP4 Antibody (FITC)

abx319786-100l 100 µl
EUR 250

Outer capsid protein VP4 Antibody (FITC)

abx319786-50l 50 µl
EUR 162.5

RHDV major capsid protein VP60 Antibody

E300729 200ul
EUR 275
Description: Available in various conjugation types.

Major Capsid Protein L1 (L1) Antibody (HRP)

20-abx317808
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Minor Capsid Protein L2 (L2) Antibody (HRP)

20-abx317812
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Minor Capsid Protein L2 (L2) Antibody (HRP)

20-abx317816
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Minor Capsid Protein L2 (L2) Antibody (HRP)

abx317812-100g 100 µg
EUR 362.5

Minor Capsid Protein L2 (L2) Antibody (HRP)

abx317812-20g 20 µg
EUR 162.5

Minor Capsid Protein L2 (L2) Antibody (HRP)

abx317812-50g 50 µg
EUR 250

Minor Capsid Protein L2 (L2) Antibody (HRP)

abx317816-100g 100 µg
EUR 362.5

Minor Capsid Protein L2 (L2) Antibody (HRP)

abx317816-20g 20 µg
EUR 162.5

Minor Capsid Protein L2 (L2) Antibody (HRP)

abx317816-50g 50 µg
EUR 250

Outer capsid protein VP4 Antibody (Biotin)

20-abx319787
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Outer capsid protein VP4 Antibody (Biotin)

abx319787-100l 100 µl
EUR 250

Outer capsid protein VP4 Antibody (Biotin)

abx319787-50l 50 µl
EUR 162.5

Major Capsid Protein L1 (L1) Antibody (FITC)

20-abx317809
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Minor Capsid Protein L2 (L2) Antibody (FITC)

20-abx317813
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Minor Capsid Protein L2 (L2) Antibody (FITC)

20-abx317817
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Minor Capsid Protein L2 (L2) Antibody (FITC)

abx317813-100g 100 µg
EUR 362.5

Minor Capsid Protein L2 (L2) Antibody (FITC)

abx317813-20g 20 µg
EUR 162.5

Minor Capsid Protein L2 (L2) Antibody (FITC)

abx317813-50g 50 µg
EUR 250

Minor Capsid Protein L2 (L2) Antibody (FITC)

abx317817-100g 100 µg
EUR 362.5

Minor Capsid Protein L2 (L2) Antibody (FITC)

abx317817-20g 20 µg
EUR 162.5

Minor Capsid Protein L2 (L2) Antibody (FITC)

abx317817-50g 50 µg
EUR 250

Capsid protein VP1 Antibody, HRP conjugated

1-CSB-PA362102LB01HPM
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  • 100ug
  • 50ug
Description: A polyclonal antibody against Capsid protein VP1. Recognizes Capsid protein VP1 from Human parvovirus B19. This antibody is HRP conjugated. Tested in the following application: ELISA

Major Capsid Protein L1 (L1) Antibody (Biotin)

20-abx317810
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Minor Capsid Protein L2 (L2) Antibody (Biotin)

20-abx317814
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Minor Capsid Protein L2 (L2) Antibody (Biotin)

20-abx317818
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

HPV18 Major capsid protein L1 Antibody (HRP)

20-abx109154
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Minor Capsid Protein L2 (L2) Antibody (Biotin)

abx317814-100g 100 µg
EUR 362.5

Minor Capsid Protein L2 (L2) Antibody (Biotin)

abx317814-20g 20 µg
EUR 162.5

Minor Capsid Protein L2 (L2) Antibody (Biotin)

abx317814-50g 50 µg
EUR 250

Minor Capsid Protein L2 (L2) Antibody (Biotin)

abx317818-100g 100 µg
EUR 362.5

Minor Capsid Protein L2 (L2) Antibody (Biotin)

abx317818-20g 20 µg
EUR 162.5

Minor Capsid Protein L2 (L2) Antibody (Biotin)

abx317818-50g 50 µg
EUR 250

Capsid protein VP1 Antibody, FITC conjugated

1-CSB-PA362102LC01HPM
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  • 100ug
  • 50ug
Description: A polyclonal antibody against Capsid protein VP1. Recognizes Capsid protein VP1 from Human parvovirus B19. This antibody is FITC conjugated. Tested in the following application: ELISA

Escherichia Phage Qbeta Capsid Protein Antibody

abx345659-100l 100 µl
EUR 350

Escherichia Phage Qbeta Capsid Protein Antibody

abx345659-50l 50 µl
EUR 250

HPV18 Major capsid protein L1 Antibody (FITC)

20-abx107736
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Intermediate capsid protein VP6 Antibody (HRP)

20-abx319789
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Intermediate capsid protein VP6 Antibody (HRP)

20-abx319793
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Minor Capsid Protein VP2 Polyclonal Antibody

A55206
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  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

Outer Capsid Protein VP4 Polyclonal Antibody

A57461
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  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

Intermediate Capsid Protein VP6 (VP6) Antibody

abx319788-100l 100 µl
EUR 250

Intermediate Capsid Protein VP6 (VP6) Antibody

abx319788-50l 50 µl
EUR 162.5

Intermediate capsid protein VP6 Antibody (HRP)

abx319789-100l 100 µl
EUR 250

Intermediate capsid protein VP6 Antibody (HRP)

abx319789-50l 50 µl
EUR 162.5

Intermediate Capsid Protein VP6 (VP6) Antibody

abx319792-100l 100 µl
EUR 250

Intermediate Capsid Protein VP6 (VP6) Antibody

abx319792-50l 50 µl
EUR 162.5

Intermediate capsid protein VP6 Antibody (HRP)

abx319793-100l 100 µl
EUR 250

Intermediate capsid protein VP6 Antibody (HRP)

abx319793-50l 50 µl
EUR 162.5

Intermediate capsid protein VP6 Antibody (FITC)

20-abx319790
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Intermediate capsid protein VP6 Antibody (FITC)

20-abx319794
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Capsid protein VP1 Antibody, Biotin conjugated

1-CSB-PA362102LD01HPM
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  • 100ug
  • 50ug
Description: A polyclonal antibody against Capsid protein VP1. Recognizes Capsid protein VP1 from Human parvovirus B19. This antibody is Biotin conjugated. Tested in the following application: ELISA

Intermediate capsid protein VP6 Antibody (FITC)

abx319790-100l 100 µl
EUR 250

Intermediate capsid protein VP6 Antibody (FITC)

abx319790-50l 50 µl
EUR 162.5

Intermediate capsid protein VP6 Antibody (FITC)

abx319794-100l 100 µl
EUR 250

Intermediate capsid protein VP6 Antibody (FITC)

abx319794-50l 50 µl
EUR 162.5

HPV18 Major capsid protein L1 Antibody (Biotin)

20-abx106323
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Intermediate capsid protein VP6 Antibody (Biotin)

20-abx319791
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Intermediate capsid protein VP6 Antibody (Biotin)

20-abx319795
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Intermediate capsid protein VP6 Antibody (Biotin)

abx319791-100l 100 µl
EUR 250

Intermediate capsid protein VP6 Antibody (Biotin)

abx319791-50l 50 µl
EUR 162.5

Intermediate capsid protein VP6 Antibody (Biotin)

abx319795-100l 100 µl
EUR 250

Intermediate capsid protein VP6 Antibody (Biotin)

abx319795-50l 50 µl
EUR 162.5

Intermediate Capsid Protein VP6 Polyclonal Antibody

A57101
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  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

Intermediate Capsid Protein VP6 Polyclonal Antibody

A55018
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  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul
When β-cells had been cultured on REP, Erk and the phosphatidylinositol 3-kinase (PI3-kinase) downstream effector, Akt was stimulated. Treatment with the Erk pathway inhibitor and PI3-kinase inhibitor decreased REP-induced β-cell adhesion and proliferation, and controlled REP-induced cell cycle proteins. Additionally, REP elevated the mRNA and protein ranges of insulin and its transcription issue, PDX-1, and insulin secretion. Our outcomes reveal that the up-regulation of the PI3K/Akt and Erk signaling pathways and the regulation of cell cycle proteins by REP may function efficient methods for enhancing pancreatic β-cell adhesion and proliferation.

A bacterial effector protein prevents MAPK-mediated phosphorylation of SGT1 to suppress plant immunity

Nucleotide-binding area and leucine-rich repeat-containing (NLR) proteins perform as sensors that understand pathogen molecules and activate immunity. In vegetation, the buildup and activation of NLRs is regulated by SUPPRESSOR OF G2 ALLELE OF skp1 (SGT1). In this work, we discovered that an effector protein named RipAC, secreted by the plant pathogen Ralstonia solanacearum, associates with SGT1 to suppress NLR-mediated SGT1-dependent immune responses, together with these triggered by one other R. solanacearum effector, RipE1. RipAC doesn’t have an effect on the buildup of SGT1 or NLRs, or their interplay. However, RipAC inhibits the interplay between SGT1 and MAP kinases, and the phosphorylation of a MAPK goal motif within the C-terminal area of SGT1.

Such phosphorylation is enhanced upon activation of immune signaling and contributes to the activation of immune responses mediated by the NLR RPS2. Additionally, SGT1 phosphorylation contributes to resistance in opposition to R. solanacearum. Our outcomes shed gentle onto the mechanism of activation of NLR-mediated immunity, and counsel a optimistic suggestions loop between MAPK activation and SGT1-dependent NLR activation. Clathrin-mediated and caveolar endocytic pathways signify the key routes by way of which G protein-coupled receptors (GPCRs) could possibly be internalized.

GPCR kinase 2 (GRK2) and β-arrestins are consultant proteins that mediate the GPCR endocytosis. However, the molecular mechanisms by way of which GRK2 and β-arrestin mediate clathrin-mediated and caveolar endocytosis stay unclear. In this research, we decided the mobile parts and processes that mediate the selective interplay between clathrin/caveolin1 and GRK2/β-arrestins. For this we utilized the next: (i) mutant dopamine D2 receptor and β2 adrenoceptor during which the potential GRK2 phosphorylation websites have been altered and (ii) cells during which clathrin, caveolin1, β-arrestins, or Mdm2 expression have been knocked down.

Overexpression of FcγRIIB regulates downstream protein phosphorylation and suppresses B cell activation to ameliorate systemic lupus erythematosus

The current research aimed to look at the consequences of FcγRIIB on systemic lupus erythematosus (SLE) and to examine the underlying mechanisms. For this function, lentiviral vector carrying the membrane‑certain sort FcγRIIB gene (mFcγRIIB lentivirus) and soluble FcγRIIB (sFcγRIIB) protein have been used to deal with B cells from sufferers with SLE. The B cells have been handled with calf thymus DNA (ctDNA) and anti‑calf thymus DNA‑immune complexes (anti‑ctDNA‑IC). mFcγRIIB lentivirus and sFcγRIIB protein have been additionally injected into MRL/lpr SLE mice.

The outcomes revealed that anti‑ctDNA‑IC therapy considerably downregulated the IgG antibody secretion of B cells handled with mFcγRIIB lentivirus. mFcγRIIB and sFcγRIIB decreased the phosphorylation stage of Bruton’s tyrosine kinase (BTK) in B cells, and elevated the phosphorylation stage of Lyn proto‑oncogene (Lyn), docking protein 1 (DOK1) and inositol polyphosphate‑5‑phosphatase D (SHIP). mFcγRIIB promoted the apoptosis of B cells. Following the therapy of MRL/lpr SLE mice with mFcγRIIB lentivirus, the degrees of urinary protein, serum anti‑nuclear and anti‑dsDNA antibodies have been decreased, whereas the degrees of mFcγRIIB in B cells have been elevated. mFcγRIIB ameliorated the pathologies of the kidneys, liver and lymph node tissues of the MRL/lpr SLE mice.

Following therapy of the MRL/lpr SLE mice with sFcγRIIB, the degrees of urinary protein, serum anti‑dsDNA antibody and BTK and SHIP phosphorylation ranges in B cells have been decreased, whereas the serum sFcγRIIB and sFcγRIIB‑IgG ranges have been elevated. On the entire, the findings of the current research show that recombinant FcγRIIB inhibits the secretion of IgG antibody by B cells from sufferers with SLE, ameliorates the signs of SLE in mice, and alters the phosphorylation ranges of downstream proteins of the FcγRIIB signaling pathway in B cells. These outcomes counsel that FcγRIIB might play preventive and therapeutic roles in SLE by inhibiting B cell activation by way of the FcγRIIB signaling pathway, which offers a novel principle and technique for the prevention and therapy of SLE.

A bacterial effector protein prevents MAPK-mediated phosphorylation of SGT1 to suppress plant immunity

Explicit illustration of protein exercise states considerably improves causal discovery of protein phosphorylation networks

Protein phosphorylation networks play an essential position in cell signaling. In these networks, phosphorylation of a protein kinase normally leads to its activation, which in flip will phosphorylate its downstream goal proteins. A phosphorylation community is actually a causal community, which might be discovered by causal inference algorithms. Prior efforts have utilized such algorithms to knowledge measuring protein phosphorylation ranges, assuming that the phosphorylation ranges signify protein exercise states. However, the phosphorylation standing of a kinase doesn’t at all times replicate its exercise state, as a result of interventions equivalent to inhibitors or mutations can instantly have an effect on its exercise state with out altering its phosphorylation standing.
Thus, when mobile techniques are subjected to intensive perturbations, the statistical relationships between phosphorylation states of proteins could also be disrupted, making it troublesome to reconstruct the true protein phosphorylation community. Here, we describe a novel framework to deal with this problem. We have developed a causal discovery framework that explicitly represents the exercise state of every protein kinase as an unmeasured variable and developed a novel algorithm referred to as “InferA” to infer the protein exercise states, which permits us to incorporate the protein phosphorylation stage, pharmacological interventions and prior information.
We utilized our framework to simulated datasets and to a real-world dataset. Our outcomes confirmed that clathrin-mediated endocytosis happens extra quickly than caveolar endocytosis. Clathrin-mediated endocytosis and the interplay between clathrin and GRK2/β-arrestin2 occurred in a GRK2-mediated receptor phosphorylation-dependent method.  In distinction, caveolar endocytosis and the interplay between caveolin1 and GRK2/β-arrestin2 have been impartial of receptor phosphorylation standing.

RECOMBINANT PROTEIN G:HRP Protein

GWB-Q00384 1 ml Ask for price

TAGLN Recombinant Protein (Rat) (Recombinant- Tag)

RP232205 100 ug Ask for price

Protein CutA Recombinant Protein

91-235 0.05 mg
EUR 821.4
Description: Protein CutA (CUTA) posseses a signal peptide and is widely expressed in brain. CUTA mayforms part of a complex of membrane proteins attached to acetylcholinesterase (AChE). CUTA takes part in cellular tolerance to a broad range of divalent cations other than copper. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found.

TAGLN2 Recombinant Protein (Rat) (Recombinant Tag)

RP232208 100 ug Ask for price

TAGLN3 Recombinant Protein (Rat) (Recombinant Tag)

RP232211 100 ug Ask for price

TAGLN3 Recombinant Protein (Rat) (Recombinant Tag)

RP232214 100 ug Ask for price

Protein FAM3C Recombinant Protein

91-317 0.05 mg
EUR 651.3
Description: FAM3C, also called interleukin-like EMT inducer, usually exist in most secretory epithelia. It belongs to the FAM3 family according to their sequence similarities. The up-regulation and/or mislocalization in breast cancer and liver carcinoma cells of FAM3C is strongly correlated with metastasis formation and survival. FAM3C can be involved in retinal laminar formation and promote epithelial to mesenchymal transition.

Protein FAM3D Recombinant Protein

91-318 0.05 mg
EUR 651.3
Description: Protein FAM3D is a novel cytokine-like protein that belongs to the FAM3 family. Human FAM3D is synthesized as a 224 amino acid precursor that contains a 25 amino acid signal sequence and a 199 amino acid mature chain. FAM3D is identified based on structural, but not sequence, homology to short chain cytokines including IL-2, IL-4 and GM-CSF. FAM3 proteins are four helix bundle cytokines with four conserved cysteines in all members (FAM3A-D). FAM3B is highly expressed in alpha and beta cells of the pancreas and is being investigated as a potential contributor to beta cell death and development of Type I Diabetes.

TAGAP Recombinant Protein (Mouse) (Recombinant- Tag)

RP177155 100 ug Ask for price

TAGLN Recombinant Protein (Mouse) (Recombinant- Tag)

RP177161 100 ug Ask for price

TAGAP Recombinant Protein (Human) (Recombinant- Tag)

RP030880 100 ug Ask for price

TAGLN Recombinant Protein (Human) (Recombinant- Tag)

RP030883 100 ug Ask for price

TAGLN Recombinant Protein (Human) (Recombinant- Tag)

RP030886 100 ug Ask for price

TAGAP Recombinant Protein (Human) (Recombinant- Tag)

RP043930 100 ug Ask for price

CTAGE5 Recombinant Protein (Mouse) (Recombinant- Tag)

RP126449 100 ug Ask for price

CTAGE5 Recombinant Protein (Mouse) (Recombinant- Tag)

RP126452 100 ug Ask for price

CTAGE5 Recombinant Protein (Mouse) (Recombinant- Tag)

RP126455 100 ug Ask for price

CTAGE1 Recombinant Protein (Human) (Recombinant- Tag)

RP008266 100 ug Ask for price

CTAGE5 Recombinant Protein (Human) (Recombinant- Tag)

RP008269 100 ug Ask for price

CTAGEP Recombinant Protein (Human) (Recombinant- Tag)

RP008275 100 ug Ask for price

Tagap1 Recombinant Protein (Mouse) (Recombinant Tag)

RP177158 100 ug Ask for price

TAGLN2 Recombinant Protein (Mouse) (Recombinant Tag)

RP177164 100 ug Ask for price

TAGLN3 Recombinant Protein (Mouse) (Recombinant Tag)

RP177167 100 ug Ask for price

TAGLN2 Recombinant Protein (Human) (Recombinant Tag)

RP030889 100 ug Ask for price

TAGLN2 Recombinant Protein (Human) (Recombinant Tag)

RP030892 100 ug Ask for price

TAGLN3 Recombinant Protein (Human) (Recombinant Tag)

RP030895 100 ug Ask for price

CTAGE4 Recombinant Protein (Human) (Recombinant- Tag)

RP053403 100 ug Ask for price

CTAGE8 Recombinant Protein (Human) (Recombinant- Tag)

RP053409 100 ug Ask for price

CTAGE9 Recombinant Protein (Human) (Recombinant- Tag)

RP053412 100 ug Ask for price

CTAG1A Recombinant Protein (Human) (Recombinant- Tag)

RP038332 100 ug Ask for price

CTAG1B Recombinant Protein (Human) (Recombinant- Tag)

RP038335 100 ug Ask for price

CTAGE5 Recombinant Protein (Human) (Recombinant- Tag)

RP038338 100 ug Ask for price

CTAGE6P Recombinant Protein (Human) (Recombinant Tag)

RP008272 100 ug Ask for price

STAG3L1 Recombinant Protein (Human) (Recombinant Tag)

RP030283 100 ug Ask for price

STAG3L2 Recombinant Protein (Human) (Recombinant Tag)

RP030286 100 ug Ask for price

STAG3L3 Recombinant Protein (Human) (Recombinant Tag)

RP030289 100 ug Ask for price

STAG3L4 Recombinant Protein (Human) (Recombinant Tag)

RP030292 100 ug Ask for price

CTAGE3P Recombinant Protein (Human) (Recombinant Tag)

RP053400 100 ug Ask for price

KC Recombinant Protein

40-339-0005mg 0.005 mg
EUR 311.1
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

KC Recombinant Protein

40-339-002mg 0.02 mg
EUR 437.1
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Recombinant Protein A

DAG390 1g
EUR 2328

Recombinant Protein L

G581 1mg
EUR 70

Recombinant Protein L

G582 10mg
EUR 245

Recombinant Protein A

G479 10 mg
EUR 105

Recombinant Protein A

G480 1 g
EUR 950

Recombinant Protein G

G481 10 mg
EUR 105

Recombinant Protein G

G482 100 mg
EUR 650

RECOMBINANT PROTEIN G

GWB-1D3798 1 mg Ask for price

Recombinant Protein G

7-05935 1mg Ask for price

Recombinant Protein G

7-05936 10mg Ask for price

Recombinant Protein G

7-05937 100mg Ask for price

TF Recombinant Protein

91-434 0.05 mg
EUR 821.4
Description: Tissue Factor (TF) is a single-pass type I membrane glycoprotein member of the tissue factor family. TF expression is highly dependent upon cell type. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. TF initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

RECOMBINANT PROTEIN G

GWB-7EB90E 5 mg Ask for price

Recombinant Protein A

RE006 10mg
EUR 179

FH Recombinant Protein

IHUFHRTF10UG each
EUR 254
Description: FH Recombinant Protein

CTAG2 Recombinant Protein (Rat) (Recombinant-P Tag)

RP196619 100 ug Ask for price

EGF Recombinant Protein

11-495 0.1 mg
EUR 651.3
Description: Human epidermal growth factor (EGF) is also known as HOMG4 and  URG,and is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR. Epidermal growth factor can be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. All family members contain one or more repeats of the conserved amino acid sequence. The biological effects of salivary EGF include healing of oral and gastroesophageal ulcers, inhibition of gastric acid secretion, stimulation of DNA synthesis as well as mucosal protection from intraluminal injurious factors such as gastric acid, bile acids, pepsin, and trypsin and to physical, chemical and bacterial agents. Because of the increased risk of cancer by EGF, inhibiting it decreases cancer risk.

CD7 Recombinant Protein

11-242 0.1 mg
EUR 714.3
Description: T-cell antigen CD7 (CD7) is also known as GP40, LEU-9, TP41 and Tp40. CD7 is a protein that in humans is encoded by the CD7 gene, this gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. CD7 has been shown to interact with PIK3R1. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.

Axl Recombinant Protein

11-290 0.1 mg
EUR 651.3
Description: AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.

HGF Recombinant Protein

11-302 0.1 mg
EUR 821.4
Description: Hepatocyte growth factor (HGF) is a paracrine cellular growth, motility and morphogenic factor. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. In addition, HGF has been implicated in a variety of cancers, including of the lungs, pancreas, thyroid, colon, and breast.

EGF Recombinant Protein

11-373 0.1 mg
EUR 651.3
Description: Human epidermal growth factor (EGF) is also known as HOMG4 and  URG,and is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR. Epidermal growth factor can be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. All family members contain one or more repeats of the conserved amino acid sequence. The biological effects of salivary EGF include healing of oral and gastroesophageal ulcers, inhibition of gastric acid secretion, stimulation of DNA synthesis as well as mucosal protection from intraluminal injurious factors such as gastric acid, bile acids, pepsin, and trypsin and to physical, chemical and bacterial agents. Because of the increased risk of cancer by EGF, inhibiting it decreases cancer risk.

AMH Recombinant Protein

30R-3463 100 ug
EUR 2244
Description: Anti Mullerian Hormone Antigen, Recombinant

AMH Recombinant Protein

30R-3464 100 ug
EUR 2493
Description: Anti Mullerian Hormone Antigen, Recombinant

p53 Recombinant Protein

39-905 0.025 mg
EUR 588.3
Description: p53 is a nuclear phosphoprotein that plays a key role in cell gwoth regulation, particularly inhibition of cell proliferation.

p62 Recombinant Protein

39-906 0.025 mg
EUR 588.3
Description: Protein p62 preferentially binds multiubiquitin chains and forms a novel cytoplasmic structure "sequestosome" which serves as a storage place for ubiquitinated proteins.

KGF Recombinant Protein

40-161-0002mg 0.002 mg
EUR 311.1
Description: Keratinocyte Growth Factor (KGF/FGF-7) is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of variety of tissues, by promoting cellular proliferation and differentiation. KGF/FG-7 is a mitogen factor specific for epithelial cells and keratinocytes and signals through FGFR 2b. KGF/FGF-7 plays a role in kidney and lung development, angiogenesis, and wound healing. Recombinant human KGF/FGF-7 is an 18.9 kDa protein consisting of 163 amino acid residues.

KGF Recombinant Protein

40-161-001mg 0.01 mg
EUR 437.1
Description: Keratinocyte Growth Factor (KGF/FGF-7) is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of variety of tissues, by promoting cellular proliferation and differentiation. KGF/FG-7 is a mitogen factor specific for epithelial cells and keratinocytes and signals through FGFR 2b. KGF/FGF-7 plays a role in kidney and lung development, angiogenesis, and wound healing. Recombinant human KGF/FGF-7 is an 18.9 kDa protein consisting of 163 amino acid residues.

HGF Recombinant Protein

40-184-0002mg 0.002 mg
EUR 311.1
Description: HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.

HGF Recombinant Protein

40-184-001mg 0.01 mg
EUR 437.1
Description: HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.

SHH Recombinant Protein

40-188-0005mg 0.005 mg
EUR 311.1
Description: Members of the Hedgehog (Hh) family are highly conserved proteins which are widely represented throughout the animal kingdom. The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh) are structurally related and share a high degree of amino-acid sequence identity (e.g., Shh and Ihh are 93% identical). The biologically active form of Hh molecules is obtained by autocatalytic cleavage of their precursor proteins and corresponds to approximately the N-terminal one half of the precursor molecule. Although Hh proteins have unique expression patterns and distinct biological roles within their respective regions of secretion, they use the same signaling pathway and can substitute for each other in experimental systems. Recombinant E. coli derived Human Sonic HedgeHog is a 20.0 kDa protein consisting of 176 amino acid residues, including an N-terminal Ile-Val-Ile sequence substituted for the natural occurring chemically modified Cys residue.

SHH Recombinant Protein

40-188-0025mg 0.025 mg
EUR 437.1
Description: Members of the Hedgehog (Hh) family are highly conserved proteins which are widely represented throughout the animal kingdom. The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh) are structurally related and share a high degree of amino-acid sequence identity (e.g., Shh and Ihh are 93% identical). The biologically active form of Hh molecules is obtained by autocatalytic cleavage of their precursor proteins and corresponds to approximately the N-terminal one half of the precursor molecule. Although Hh proteins have unique expression patterns and distinct biological roles within their respective regions of secretion, they use the same signaling pathway and can substitute for each other in experimental systems. Recombinant E. coli derived Human Sonic HedgeHog is a 20.0 kDa protein consisting of 176 amino acid residues, including an N-terminal Ile-Val-Ile sequence substituted for the natural occurring chemically modified Cys residue.

TSG Recombinant Protein

40-205-001mg 0.01 mg
EUR 311.1
Description: Twisted Gastrulation Protein (TSG) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins, and can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex. Recombinant human TSG is a 199 amino acid 22.2 kDa protein containing the BMP/TGFβ binding portion of the full length TSG protein.

TSG Recombinant Protein

40-205-005mg 0.05 mg
EUR 437.1
Description: Twisted Gastrulation Protein (TSG) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins, and can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex. Recombinant human TSG is a 199 amino acid 22.2 kDa protein containing the BMP/TGFβ binding portion of the full length TSG protein.

NOV Recombinant Protein

40-222-0005mg 0.005 mg
EUR 311.1
Description: NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm’s tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities. Recombinant human NOV is a 36.2 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).

NOV Recombinant Protein

40-222-002mg 0.02 mg
EUR 437.1
Description: NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm’s tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities. Recombinant human NOV is a 36.2 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).

MIA Recombinant Protein

40-226-0005mg 0.005 mg
EUR 311.1
Description: MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family; MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2 kDa globular protein containing 108 amino acid residues including two intramolecular disulfide bonds.

MIA Recombinant Protein

40-226-002mg 0.02 mg
EUR 437.1
Description: MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family; MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2 kDa globular protein containing 108 amino acid residues including two intramolecular disulfide bonds.

SCF Recombinant Protein

40-282-0002mg 0.002 mg
EUR 311.1
Description: Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. Recombinant human SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.

SCF Recombinant Protein

40-282-001mg 0.01 mg
EUR 437.1
Description: Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. Recombinant human SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.

C10 Recombinant Protein

40-334-0002mg 0.002 mg
EUR 311.1
Description: Murine C10 belongs to the CC chemokine family and is expressed in myelopoietic bone marrow cultures when stimulated with GM-CSF, M-CSF, IL-3 or IL-4. It signals primarily through the CCR1 receptor. C10 is chemotactic for B cells, CD4+ T cells, monocytes and NK cells and also exhibits powerful suppressive activity on colony formation by different lineages of hematopoietic progenitors. The C10 contains the four highly conserved cysteine residues present in CC chemokines. The mature protein contains 95 amino acid residues. Recombinant murine C-10 is a 10.7 kDa protein containing 95 amino acid residues.

C10 Recombinant Protein

40-334-001mg 0.01 mg
EUR 437.1
Description: Murine C10 belongs to the CC chemokine family and is expressed in myelopoietic bone marrow cultures when stimulated with GM-CSF, M-CSF, IL-3 or IL-4. It signals primarily through the CCR1 receptor. C10 is chemotactic for B cells, CD4+ T cells, monocytes and NK cells and also exhibits powerful suppressive activity on colony formation by different lineages of hematopoietic progenitors. The C10 contains the four highly conserved cysteine residues present in CC chemokines. The mature protein contains 95 amino acid residues. Recombinant murine C-10 is a 10.7 kDa protein containing 95 amino acid residues.

LIX Recombinant Protein

40-345-0005mg 0.005 mg
EUR 311.1
Description: CXCL6, also known as GCP-2 in humans and LIX in mice, is a connective tissue-derived CXC chemokine that contains the four conserved cysteine residues shared by CXC chemokines and the ‘ELR’ motif responsible for CXCR1 and CXCR2 receptor signaling. Constitutively expressed in monocytes, platelets, endothelial cells and mast cells, CXCL6 selectively chemoattracts neutrophils and has been shown to exert anti-angiogenic activity. Human GCP-2 and murine LIX respectively exhibit murine and human cell cross-reactivity. There are two naturally occurring variants of murine LIX, the 78 amino-acid-length LIX 1-78 (GCP-2) and the 70 amino-acid-length LIX 9-78 (GCP-2).

LIX Recombinant Protein

40-345-002mg 0.02 mg
EUR 437.1
Description: CXCL6, also known as GCP-2 in humans and LIX in mice, is a connective tissue-derived CXC chemokine that contains the four conserved cysteine residues shared by CXC chemokines and the ‘ELR’ motif responsible for CXCR1 and CXCR2 receptor signaling. Constitutively expressed in monocytes, platelets, endothelial cells and mast cells, CXCL6 selectively chemoattracts neutrophils and has been shown to exert anti-angiogenic activity. Human GCP-2 and murine LIX respectively exhibit murine and human cell cross-reactivity. There are two naturally occurring variants of murine LIX, the 78 amino-acid-length LIX 1-78 (GCP-2) and the 70 amino-acid-length LIX 9-78 (GCP-2).

MIG Recombinant Protein

40-346-0005mg 0.005 mg
EUR 311.1
Description: MIG, a CXC chemokine, is produced by IFN?× stimulated monocytes, macrophages and endothelial cells. It signals through the CXCR3 receptor. MIG selectively chemoattracts Th1 lymphocytes, and also exerts other activities including inhibition of tumor growth, angiogenesis, and inhibition of colony formation of hematopoietic progenitors. Human MIG is active on murine cells. Recombinant murine MIG is a 12.2 kDa protein containing 105 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.

MIG Recombinant Protein

40-346-002mg 0.02 mg
EUR 437.1
Description: MIG, a CXC chemokine, is produced by IFN?× stimulated monocytes, macrophages and endothelial cells. It signals through the CXCR3 receptor. MIG selectively chemoattracts Th1 lymphocytes, and also exerts other activities including inhibition of tumor growth, angiogenesis, and inhibition of colony formation of hematopoietic progenitors. Human MIG is active on murine cells. Recombinant murine MIG is a 12.2 kDa protein containing 105 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.

MDC Recombinant Protein

40-350-0005mg 0.005 mg
EUR 311.1
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

MDC Recombinant Protein

40-350-002mg 0.02 mg
EUR 437.1
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

BLC Recombinant Protein

40-351-0005mg 0.005 mg
EUR 311.1
Description: BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes. Recombinant murine BLC is a 9.8 kDa protein containing 88 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines.

BLC Recombinant Protein

40-351-002mg 0.02 mg
EUR 437.1
Description: BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes. Recombinant murine BLC is a 9.8 kDa protein containing 88 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines.

MEC Recombinant Protein

40-357-0005mg 0.005 mg
EUR 311.1
Description: MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant murine MEC is a 12.6 kDa protein containing 111 amino acid residues.

MEC Recombinant Protein

40-357-002mg 0.02 mg
EUR 437.1
Description: MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant murine MEC is a 12.6 kDa protein containing 111 amino acid residues.

LIX Recombinant Protein

40-359-0005mg 0.005 mg
EUR 311.1
Description: CXCL6, also known as GCP-2 in humans and LIX in mice, is a connective tissue-derived CXC chemokine that contains the four conserved cysteine residues shared by CXC chemokines and the ‘ELR’ motif responsible for CXCR1 and CXCR2 receptor signaling. Constitutively expressed in monocytes, platelets, endothelial cells and mast cells, CXCL6 selectively chemoattracts neutrophils and has been shown to exert anti-angiogenic activity. Human GCP-2 and murine LIX respectively exhibit murine and human cell cross-reactivity. There are two naturally occurring variants of murine LIX, the 78 amino-acid-length LIX 1-78 (GCP-2) and the 70 amino-acid-length LIX 9-78 (GCP-2).

LIX Recombinant Protein

40-359-002mg 0.02 mg
EUR 437.1
Description: CXCL6, also known as GCP-2 in humans and LIX in mice, is a connective tissue-derived CXC chemokine that contains the four conserved cysteine residues shared by CXC chemokines and the ‘ELR’ motif responsible for CXCR1 and CXCR2 receptor signaling. Constitutively expressed in monocytes, platelets, endothelial cells and mast cells, CXCL6 selectively chemoattracts neutrophils and has been shown to exert anti-angiogenic activity. Human GCP-2 and murine LIX respectively exhibit murine and human cell cross-reactivity. There are two naturally occurring variants of murine LIX, the 78 amino-acid-length LIX 1-78 (GCP-2) and the 70 amino-acid-length LIX 9-78 (GCP-2).

MIG Recombinant Protein

40-376-0005mg 0.005 mg
EUR 311.1
Description: MIG, a CXC chemokine, is produced by IFN stimulated monocytes, macrophages and endothelial cells. It signals through the CXCR3 receptor. MIG selectively chemoattracts Th1 lymphocytes, and also exerts other activities including inhibition of tumor growth, angiogenesis, and inhibition of colony formation of hematopoietic progenitors. Human MIG is active on murine cells. Recombinant human MIG is an 11.7 kDa protein containing 103 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.

MIG Recombinant Protein

40-376-002mg 0.02 mg
EUR 437.1
Description: MIG, a CXC chemokine, is produced by IFN stimulated monocytes, macrophages and endothelial cells. It signals through the CXCR3 receptor. MIG selectively chemoattracts Th1 lymphocytes, and also exerts other activities including inhibition of tumor growth, angiogenesis, and inhibition of colony formation of hematopoietic progenitors. Human MIG is active on murine cells. Recombinant human MIG is an 11.7 kDa protein containing 103 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.

MDC Recombinant Protein

40-387-0005mg 0.005 mg
EUR 311.1
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

MDC Recombinant Protein

40-387-002mg 0.02 mg
EUR 437.1
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

MDC Recombinant Protein

40-388-0005mg 0.005 mg
EUR 311.1
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.1 kDa protein containing 69 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

MDC Recombinant Protein

40-388-002mg 0.02 mg
EUR 437.1
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.1 kDa protein containing 69 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

LEC Recombinant Protein

40-396-0005mg 0.005 mg
EUR 311.1
Description: LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

LEC Recombinant Protein

40-396-002mg 0.02 mg
EUR 437.1
Description: LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

BLC Recombinant Protein

40-399-0005mg 0.005 mg
EUR 311.1
Description: BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes. Recombinant Human BCA-1 is a 10.3 kDa protein containing 87 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines.

BLC Recombinant Protein

40-399-002mg 0.02 mg
EUR 437.1
Description: BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes. Recombinant Human BCA-1 is a 10.3 kDa protein containing 87 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines.

MEC Recombinant Protein

40-405-0005mg 0.005 mg
EUR 311.1
Description: MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant human MEC is a 12.3 kDa protein containing 108 amino acid residues.

MEC Recombinant Protein

40-405-002mg 0.02 mg
EUR 437.1
Description: MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant human MEC is a 12.3 kDa protein containing 108 amino acid residues.

GRO Recombinant Protein

40-408-0005mg 0.005 mg
EUR 311.1
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

GRO Recombinant Protein

40-408-0025mg 0.025 mg
EUR 437.1
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

SCF Recombinant Protein

40-438-0002mg 0.002 mg
EUR 311.1
Description: SCF is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. Recombinant murine SCF is an 18.3 kDa polypeptide containing 164 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.

SCF Recombinant Protein

40-438-001mg 0.01 mg
EUR 437.1
Description: SCF is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. Recombinant murine SCF is an 18.3 kDa polypeptide containing 164 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.

EGF Recombinant Protein

40-450-01mg 0.1 mg
EUR 311.1
Description: Epidermal Growth Factor (EGF) is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF-alpha and VGF (vaccinia virus growth factor). Recombinant murine EGF is a 6.0 kDa globular protein containing 53 amino acid residues, including 3 intramolecular disulfide-bonds.

EGF Recombinant Protein

40-450-05mg 0.5 mg
EUR 437.1
Description: Epidermal Growth Factor (EGF) is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF-alpha and VGF (vaccinia virus growth factor). Recombinant murine EGF is a 6.0 kDa globular protein containing 53 amino acid residues, including 3 intramolecular disulfide-bonds.

SCF Recombinant Protein

40-474-0002mg 0.002 mg
EUR 311.1
Description: Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. Recombinant rat SCF is an 18.4 kDa polypeptide containing 154 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.

SCF Recombinant Protein

40-474-001mg 0.01 mg
EUR 437.1
Description: Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. Recombinant rat SCF is an 18.4 kDa polypeptide containing 154 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.

EGF Recombinant Protein

40-477-002mg 0.02 mg
EUR 311.1
Description: EGF is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF-α and VGF (vaccinia virus growth factor). Recombinant rat EGF is a 6.2 kDa globular protein containing 54 amino acid residues including 3 intramolecular disulfide-bonds.

EGF Recombinant Protein

40-477-01mg 0.1 mg
EUR 437.1
Description: EGF is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF-α and VGF (vaccinia virus growth factor). Recombinant rat EGF is a 6.2 kDa globular protein containing 54 amino acid residues including 3 intramolecular disulfide-bonds.

SCF Recombinant Protein

40-535 0.01 mg
EUR 481.2
Description: SCF is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. Recombinant murine SCF is an 18.3 kDa polypeptide containing 164 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.

HGF Recombinant Protein

40-580-0005mg 0.005 mg
EUR 311.1
Description: HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Murine HGF is expressed as a linear 728 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 233 amino acid residues.*Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

HGF Recombinant Protein

40-580-002mg 0.02 mg
EUR 437.1
Description: HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Murine HGF is expressed as a linear 728 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 233 amino acid residues.*Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

TPO Recombinant Protein

40-585-0002mg 0.002 mg
EUR 311.1
Description: TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.

TPO Recombinant Protein

40-585-001mg 0.01 mg
EUR 437.1
Description: TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.

EGF Recombinant Protein

40-586-01mg 0.1 mg
EUR 311.1
Description: EGF is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF-a and VGF (vaccinia virus growth factor). Recombinant human EGF is a 6.2 kDa globular protein containing 53 amino acid residues including 3 intramolecular disulfide-bonds.

EGF Recombinant Protein

40-586-05mg 0.5 mg
EUR 437.1
Description: EGF is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF-a and VGF (vaccinia virus growth factor). Recombinant human EGF is a 6.2 kDa globular protein containing 53 amino acid residues including 3 intramolecular disulfide-bonds.

KGF Recombinant Protein

40-605 0.01 mg
EUR 481.2
Description: KGF/FGF-7 is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. KGF/FGF-7 is a mitogen factor specific for epithelial cells and keratinocytes. KGF/FGF-7 signals through FGFR 2b. KGF/FGF-7 plays a role in kidney and lung development, angiogenesis, and wound healing. Recombinant human KGF/FGF-7 is a 18.9 kDa protein consisting of 163 amino acid residues.

SCF Recombinant Protein

40-608 0.01 mg
EUR 481.2
Description: SCF is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. Recombinant human SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.
The simulation experiments demonstrated that express illustration of exercise states of protein kinases permits one to successfully signify the influence of interventions and thus enabled our framework to precisely recuperate the ground-truth causal community. Results from the real-world dataset confirmed that the express illustration of protein exercise states allowed an efficient and data-driven integration of the prior information by InferA, which additional leads to the restoration of a phosphorylation community that’s extra according to experiment outcomes.

Protein phosphorylation in depolarized synaptosomes: Dissecting primary effects of calcium from synaptic vesicle cycling

Synaptic transmission is mediated by the regulated exocytosis of synaptic vesicles. When the presynaptic membrane is depolarized by an incoming motion potential, voltage-gated calcium channels open, ensuing in the inflow of calcium ions that triggers the fusion of synaptic vesicles (SV) with the plasma membrane. SV are recycled by endocytosis. Phosphorylation of synaptic proteins performs a significant function in these processes, and a number of other research have proven that the synaptic phosphoproteome adjustments quickly in response to depolarization. However, it’s unclear which of these adjustments are immediately linked to SV-cycling and which could regulate different presynaptic features which are additionally managed by calcium-dependent kinases and phosphatases.

To deal with this query, we analyzed adjustments in the phosphoproteome utilizing rat synaptosomes in which exocytosis was blocked with botulinum neurotoxins (BoNTs) whereas depolarization-induced calcium inflow remained unchanged. BoNT-treatment considerably alters the response of the synaptic phoshoproteome to depolarization and outcomes in decreased phosphorylation ranges when in comparison with stimulation of synaptosomes by depolarization with KCl alone. We dissect the primary Ca2+-dependent phosphorylation from SV-cycling dependent phosphorylation and ensure an impact of such SV-cycling-dependent phosphorylation occasions on syntaxin-1a-T21/T23, Vamp2-S75, and cannabinoid receptor-1-S314/T322 on exo- and endocytosis in cultured hippocampal neurons.

We examined signaling variations between two co-stimulatory molecules, CD28 and ICAM-1 by analyzing transcription elements and proteins which are activated downstream of these co-stimulations. We noticed that FAST-1, an important protein in the TGFβ signaling pathway, was activated by solely ICAM-1 co-stimulation, and never by CD28. We additionally noticed that receptor tyrosine kinases Csk, Dtk, FGFR1 and ROR2 had been phosphorylated upon CD28 co-stimulation and IGF-1R, HGFR, MuSK and EphA8 had been phosphorylated upon ICAM-1 co-stimulation. Together, these findings recommend that these two co-stimulators induce the activation of completely different units of proteins, suggesting that every co-stimulatory molecule has its distinctive signaling profile.

Phosphorylation-regulated HMGA1a-P53 interplay unveils the operate of HMGA1a acidic tail phosphorylations through artificial proteins

As a typical member of intrinsically disordered proteins (IDPs), HMGA1a carries many post-translational modifications (PTMs). To examine the undefined operate of acidic tail phosphorylations, seven HMGA1a proteins with site-specific modification(s) had been chemically synthesized through Ser/Thr ligation. We discovered that the phosphorylations considerably inhibit HMGA1a-P53 interplay and the phosphorylations can induce conformational change of HMGA1a from an “open state” to a “shut state.” Notably, the positively charged lysine-arginine (KR) clusters are chargeable for modulating HMGA1a conformation through electrostatic interplay with the phosphorylated acidic tail.

Finally, we used an artificial protein-affinity purification mass spectrometry (SP-AP-MS) methodology to profile the particular interactors, which additional supported the operate of HMGA1a phosphorylation. Collectively, this examine highlights a mechanism for regulating IDPs’ conformation and performance by phosphorylation of non-protein-binding area and showcases that the protein chemical synthesis in mixture with mass spectrometry can function an environment friendly software to check the IDPs’ PTMs. SNTA1 protein ranges and phosphorylation standing had been decided in MDA-MB-231 cells publish jasplakinolide publicity utilizing western blotting and immunoprecipitation strategies respectively.

Lipopolysaccharide (LPS)-induced macrophage activation is a prototype of innate immune response. Although key effector proteins in LPS signaling pathway have been revealed, the map of dynamic protein interactions and phosphorylation in addition to the stoichiometry of protein complexes are missing. Here we current a dynamic map of protein interactions and phosphorylation in MyD88, TRAF6 and NEMO complexes obtained by SWATH-MS. The complete MS measurement results in quantification of as much as about 3,000 proteins throughout about 21-40 IP samples. We detected and quantified virtually all recognized interactors of MyD88, TRAF6 and NEMO.

By analyzing these quantitative information, we uncovered differential recruitment of IRAK household proteins to LPS-induced signaling complexes and decided the stoichiometry of the Myddosome complicated. In addition, quantitative phosphoproteomics evaluation recognized a quantity of unreported high-confidence phosphosites on the important thing proteins in LPS signaling pathway. Collectively, information of dynamic protein interactions and phosphorylation introduced by this examine might be a useful resource for additional examine of the LPS signaling pathway.

Protein phosphorylation in depolarized synaptosomes: Dissecting primary effects of calcium from synaptic vesicle cycling

Jasplakinolide Attenuates Cell Migration by Impeding Alpha-1-syntrophin Protein Phosphorylation in Breast Cancer Cells

Alpha-1-syntrophin (SNTA1) is rising as a novel modulator of the actin cytoskeleton. SNTA1 binds to F-actin and regulates intracellular localization and exercise of varied actin organizing signaling molecules. Aberration in syntrophin signaling has been intently linked with deregulated progress linked to tumor growth/metastasis and its irregular over expression has been noticed in breast most cancers. In the current work the impact of jasplakinolide, an actin-binding cyclodepsipeptide, on the SNTA1 protein exercise and SNTA1 mediated downstream mobile occasions was studied in MDA-MB-231 breast most cancers cell line.

Prion Protein(PrP) Antibody

48939 100ul
EUR 499

Prion Protein(PrP) Antibody

48939-100ul 100ul
EUR 399.6

Prion Protein(PrP) Antibody

48939-50ul 50ul
EUR 286.8

Prion Protein (PrP) Antibody

abx120080-01ml 0.1 ml
EUR 944.4

PrP Antibody / Prion protein

RQ5040 100ul
EUR 356.15
Description: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. [RefSeq]

PrP Antibody Prion protein

R30892 100 ug
EUR 356.15
Description: Prion protein, also known as CD230 and PrP, is a protein that in humans is encoded by the PRNP gene. Expression is predominantly in the nervous system but occurs to some degree in many other tissues throughout the body. Puckett et al.(1991)identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP gene, which might serve as a useful marker for the pter-p12 region of chromosome 20. PrP is associated with a variety of cognitive deficiencies and neurodegenerative diseases such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru. The protein is highly conserved through mammals, lending credence to application of conclusions from test animals such as mice. Comparison between primates is especially similar, ranging from 92.9-99.6% similarity in amino acid sequences.

Prion Protein (PRNP) Antibody

abx431521-200ul 200 ul
EUR 460.8

Prion Protein (PRNP) Antibody

20-abx101113
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Prion Protein (PRNP) Antibody

20-abx101114
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Prion Protein (PRNP) Antibody

20-abx174157
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  • 1 mg
  • 200 ug

Prion Protein (PRNP) Antibody

abx120079-01ml 0.1 ml
EUR 1779.6

Prion Protein (PRNP) Antibody

20-abx114678
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  • 150 ul
  • 50 ul

Prion Protein (PRNP) Antibody

abx002019-100l 100 µl
EUR 387.5

Prion Protein (PRNP) Antibody

abx002019-20l 20 µl
EUR 175

Prion Protein (PRNP) Antibody

abx002019-50l 50 µl
EUR 275

Prion Protein (PRNP) Antibody

abx227053-100g 100 µg
EUR 325

Prion Protein (PRNP) Antibody

abx114678-100l 100 µl
EUR 612.5

Prion Protein (PRNP) Antibody

abx139819-100g 100 µg
EUR 425

Prion Protein (PRNP) Antibody

abx101113-100l 100 µl
EUR 262.5

Prion Protein (PRNP) Antibody

abx101113-1ml 1 ml
EUR 712.5

Prion Protein (PRNP) Antibody

abx101113-200l 200 µl
EUR 325

Prion Protein (PRNP) Antibody

abx101114-100l 100 µl
EUR 262.5

Prion Protein (PRNP) Antibody

abx101114-1ml 1 ml
EUR 725

Prion Protein (PRNP) Antibody

abx101114-200l 200 µl
EUR 337.5

Prion Protein (PRNP) Antibody

abx174157-100l 100 µl
EUR 750

Prion Protein (PRNP) Antibody

abx174157-1ml 1 ml Ask for price

Prion Protein (PRNP) Antibody

abx174157-200l 200 µl Ask for price

Prion Protein (PRNP) Antibody

abx319681-100l 100 µl
EUR 250

Prion Protein (PRNP) Antibody

abx319681-50l 50 µl
EUR 162.5

Prion Protein (PRNP) Antibody

abx431521-200l 200 µl
EUR 387.5

Prion Protein (PRNP) Antibody

abx333875-100g 100 µg
EUR 362.5

Prion Protein (PRNP) Antibody

abx333875-20g 20 µg
EUR 162.5

Prion Protein (PRNP) Antibody

abx333875-50g 50 µg
EUR 250

Prion Protein (PRNP) Antibody

abx414218-200l 200 µl
EUR 512.5

Prion Protein (PRNP) Antibody

abx415314-200l 200 µl
EUR 362.5

Prion Protein (PRNP) Antibody

abx415315-200l 200 µl
EUR 362.5

Prion Protein (PRNP) Antibody

abx415316-200l 200 µl
EUR 362.5

Prion Protein (PrPsc), Antibody

GWB-8BFFBE 0.1 mg Purified Ask for price

Polyclonal Prion Protein Antibody

APR12947G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Chicken that recognizes and binds to Human Prion Protein . This antibody is tested and proven to work in the following applications:

Prion Protein Polyclonal Antibody

E-AB-92393-120uL 120uL
EUR 320
Description: Unconjugated

Prion Protein Polyclonal Antibody

E-AB-92393-200uL 200uL
EUR 530
Description: Unconjugated

Prion Protein Polyclonal Antibody

E-AB-92393-60uL 60uL
EUR 200
Description: Unconjugated

Prion Protein Polyclonal Antibody

E-AB-92393-each each Ask for price
Description: Unconjugated

Prion Protein 2 (PRND) Antibody

20-abx114679
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  • 150 ul
  • 50 ul

Prion Protein 2 (PRND) Antibody

abx114679-100l 100 µl
EUR 612.5

Prion Protein (PRNP) Antibody (HRP)

abx319682-100l 100 µl
EUR 250

Prion Protein (PRNP) Antibody (HRP)

abx319682-50l 50 µl
EUR 162.5

Prion Protein (PRNP) Antibody (HRP)

abx336435-100g 100 µg
EUR 362.5

Prion Protein (PRNP) Antibody (HRP)

abx336435-20g 20 µg
EUR 162.5

Prion Protein (PRNP) Antibody (HRP)

abx336435-50g 50 µg
EUR 250

Prion Protein (PRNP) Antibody Pair

20-abx370619
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  • 10 × 96 tests
  • 5 × 96 tests

Prion Protein (PRNP) Antibody Pair

20-abx370620
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  • 10 × 96 tests
  • 5 × 96 tests

Prion Protein (PRNP) Antibody Pair

20-abx370621
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  • 10 × 96 tests
  • 5 × 96 tests

Prion Protein (PRNP) Antibody (FITC)

abx319683-100l 100 µl
EUR 250

Prion Protein (PRNP) Antibody (FITC)

abx319683-50l 50 µl
EUR 162.5

Prion Protein (PRNP) Antibody Pair

abx370619-100g 100 µg
EUR 2550

Prion Protein (PRNP) Antibody Pair

abx370619-50g 50 µg
EUR 1575

Prion Protein (PRNP) Antibody Pair

abx370620-100g 100 µg
EUR 2312.5

Prion Protein (PRNP) Antibody Pair

abx370620-50g 50 µg
EUR 1437.5

Prion Protein (PRNP) Antibody Pair

abx370621-100g 100 µg
EUR 2250

Prion Protein (PRNP) Antibody Pair

abx370621-50g 50 µg
EUR 1400

Prion Protein (PRNP) Antibody (FITC)

abx336436-100g 100 µg
EUR 362.5

Prion Protein (PRNP) Antibody (FITC)

abx336436-20g 20 µg
EUR 162.5

Prion Protein (PRNP) Antibody (FITC)

abx336436-50g 50 µg
EUR 250

Major Prion Protein (PRNP) Antibody

20-abx319681
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  • 100 ug
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Major Prion Protein (PRNP) Antibody

20-abx333875
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  • 100 ug
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  • 200 ug
  • 20 ug
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Major Prion Protein (PRNP) Antibody

20-abx002019
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  • 100 ul
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Major Prion Protein (PRNP) Antibody

abx140599-100g 100 µg
EUR 425

Major Prion Protein (CD230) Antibody

abx412470-01ml 0.1 ml
EUR 844.8

Major Prion Protein (CD230) Antibody

abx415314-01mg 0.1 mg
EUR 543.6

Major Prion Protein (CD230) Antibody

abx415315-01mg 0.1 mg
EUR 543.6

Major Prion Protein (CD230) Antibody

abx415316-01mg 0.1 mg
EUR 543.6

Major Prion Protein (CD230) Antibody

20-abx141693
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  • 100 ul
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Major Prion Protein (CD230) Antibody

abx139819-01mg 0.1 mg
EUR 610.8

Prion Protein (PRNP) Antibody (Biotin)

abx319684-100l 100 µl
EUR 250

Prion Protein (PRNP) Antibody (Biotin)

abx319684-50l 50 µl
EUR 162.5

Prion Protein (PRNP) Antibody (Biotin)

abx336437-100g 100 µg
EUR 362.5

Prion Protein (PRNP) Antibody (Biotin)

abx336437-20g 20 µg
EUR 162.5

Prion Protein (PRNP) Antibody (Biotin)

abx336437-50g 50 µg
EUR 250

Rabbit Polyclonal Prion protein Antibody

TA590315 100 µg Ask for price

Rabbit Polyclonal Prion protein Antibody

TA336429 100 µg Ask for price

Rabbit Polyclonal Prion protein Antibody

TA336430 100 µg Ask for price

Rabbit Polyclonal Prion protein Antibody

TA336431 100 µg Ask for price

Prion Protein(PrP) Conjugated Antibody

C48939 100ul
EUR 476.4

Prion Protein (PRNP) Polyclonal Antibody

CAU25509-100ul 100ul
EUR 229.4

Prion Protein (PRNP) Polyclonal Antibody

CAU25509-200ul 200ul
EUR 287.3

Prion Protein (PRNP) Polyclonal Antibody

CAU25510-100ul 100ul
EUR 222.7

Prion Protein (PRNP) Polyclonal Antibody

CAU25510-200ul 200ul
EUR 278.9

Prion Protein Rabbit Monoclonal Antibody

E10G21880 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Prion Protein Rabbit Polyclonal Antibody

E10G22816 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Prion Protein-Interacting Protein (PRNIP) Antibody

abx032619-400ul 400 ul
EUR 627.6

Prion Protein-Interacting Protein (PRNIP) Antibody

abx032619-80l 80 µl
EUR 343.2

Prion Protein-Interacting Protein (PRNIP) Antibody

abx032619-400l 400 µl
EUR 518.75

Major Prion Protein (PRNP) Antibody (HRP)

20-abx336435
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Major Prion Protein (PRNP) Antibody (HRP)

20-abx319682
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  • 100 ug
  • 1 mg
  • 200 ug
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Shadow Of Prion Protein (SPRN) Antibody

20-abx339404
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  • 100 ul
  • 50 ul

Shadow of Prion Protein (SPRN) Antibody

abx032300-400ul 400 ul
EUR 627.6

Shadow of Prion Protein (SPRN) Antibody

abx032300-80l 80 µl
EUR 343.2

Shadow of Prion Protein (SPRN) Antibody

abx032300-200l 200 µl
EUR 518.75

Shadow of Prion Protein (SPRN) Antibody

abx032300-50l 50 µl
EUR 281.25

Shadow Of Prion Protein (SPRN) Antibody

abx339404-100l 100 µl
EUR 350

Shadow Of Prion Protein (SPRN) Antibody

abx339404-50l 50 µl
EUR 250

Major Prion Protein (PRNP) Antibody (FITC)

20-abx336436
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Major Prion Protein (PRNP) Antibody (FITC)

20-abx319683
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Prion Protein recombinant monoclonal antibody

A5436 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human Prion Protein for WB, IHC,ELISA

Major Prion Protein (PRNP) Antibody (Biotin)

20-abx336437
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
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Major Prion Protein (PRNP) Antibody (Biotin)

20-abx319684
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  • 100 ug
  • 1 mg
  • 200 ug
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Polyclonal Antibody to Prion Protein (PRNP)

PAB680Hu01 100ul
EUR 232

Polyclonal Antibody to Prion Protein (PRNP)

PAB680Hu02 100ul
EUR 240

Polyclonal Antibody to Prion Protein (PRNP)

PAB680Mu01 100ul
EUR 239

Prion Protein (PRNP) Polyclonal Antibody (Rat, Mouse)

4-PAB680Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat, Mouse Prion Protein (PRNP)

Prion Protein (PRNP) Polyclonal Antibody (Mouse, Rat)

4-PAB680Mu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Prion Protein (PRNP)

Prion protein PrP (PRNP) chicken polyclonal antibody

CH23027-200 200 µl Ask for price

Goat Polyclonal Antibody against Prion Protein (143-153)

TA302683 100 µg Ask for price

Anti- Prion protease-resistant protein 27-30 (PrP27-30) N-Terminal Antibody

GWB-8D9823 0.25 ml Ask for price

Anti- Prion protease-resistant protein 27-30 (PrP27-30) N-Terminal Antibody

GWB-92178F 0.1 ml Ask for price

Prion-Like Protein Doppel (PRND) Antibody

20-abx322158
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  • 100 ul
  • 50 ul

Prion-Like Protein Doppel (PRND) Antibody

20-abx320384
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  • 100 ul
  • 50 ul

Prion-Like Protein Doppel (Prnd) Antibody

abx236794-100ug 100 ug
EUR 661.2

Prion-Like Protein Doppel (PRND) Antibody

20-abx006423
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  • 100 ul
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Prion-Like Protein Doppel (Prnd) Antibody

abx236794-100g 100 µg
EUR 350

Prion-Like Protein Doppel (PRND) Antibody

abx320384-100l 100 µl
EUR 350

Prion-Like Protein Doppel (PRND) Antibody

abx320384-50l 50 µl
EUR 237.5

Prion-Like Protein Doppel (PRND) Antibody

abx322158-100g 100 µg
EUR 350

Prion-Like Protein Doppel (PRND) Antibody

abx322158-50g 50 µg
EUR 237.5

Prion Protein (PRNP) Polyclonal Antibody (Rat, Mouse), PE

4-PAB680Hu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat, Mouse Prion Protein (PRNP). This antibody is labeled with PE.

Prion Protein (PRNP) Polyclonal Antibody (Mouse, Rat), PE

4-PAB680Mu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Prion Protein (PRNP). This antibody is labeled with PE.

Prion Protein (PRNP) Polyclonal Antibody (Rat, Mouse), APC

4-PAB680Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat, Mouse Prion Protein (PRNP). This antibody is labeled with APC.

Prion Protein (PRNP) Polyclonal Antibody (Rat, Mouse), Cy3

4-PAB680Hu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat, Mouse Prion Protein (PRNP). This antibody is labeled with Cy3.

Prion Protein (PRNP) Polyclonal Antibody (Rat, Mouse), HRP

4-PAB680Hu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat, Mouse Prion Protein (PRNP). This antibody is labeled with HRP.

Prion Protein (PRNP) Polyclonal Antibody (Mouse, Rat), APC

4-PAB680Mu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Prion Protein (PRNP). This antibody is labeled with APC.

Prion Protein (PRNP) Polyclonal Antibody (Mouse, Rat), Cy3

4-PAB680Mu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Mouse, Rat Prion Protein (PRNP). This antibody is labeled with Cy3.

Prion Protein (PRNP) Polyclonal Antibody (Mouse, Rat), HRP

4-PAB680Mu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Mouse, Rat Prion Protein (PRNP). This antibody is labeled with HRP.

Prion protein PrP (PRNP) goat polyclonal antibody, Serum

AP05815PU-N 100 µl Ask for price

Prion Protein (PRNP) Polyclonal Antibody (Rat, Mouse), FITC

4-PAB680Hu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat, Mouse Prion Protein (PRNP). This antibody is labeled with FITC.

Prion Protein (PRNP) Polyclonal Antibody (Mouse, Rat), FITC

4-PAB680Mu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Prion Protein (PRNP). This antibody is labeled with FITC.

Prion Protein (PRNP) Polyclonal Antibody (Rat, Mouse), Biotinylated

4-PAB680Hu01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Rat, Mouse Prion Protein (PRNP). This antibody is labeled with Biotin.

Prion Protein (PRNP) Polyclonal Antibody (Mouse, Rat), Biotinylated

4-PAB680Mu01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Prion Protein (PRNP). This antibody is labeled with Biotin.

Prion Protein (PRNP) Polyclonal Antibody (Rat, Mouse), APC-Cy7

4-PAB680Hu01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat, Mouse Prion Protein (PRNP). This antibody is labeled with APC-Cy7.

Prion Protein (PRNP) Polyclonal Antibody (Mouse, Rat), APC-Cy7

4-PAB680Mu01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Prion Protein (PRNP). This antibody is labeled with APC-Cy7.

Prion, Antibody

GWB-576BE1 0.25 ml Ask for price

Prion Protein (PrP)

E8ET1610-27 100ul
EUR 275
Description: Available in various conjugation types.

Prion Protein/CD230

CH23027 200 ul
EUR 553.2

Major prion protein

AP79467 1mg
EUR 2640

Major prion protein

AP79468 1mg
EUR 2640

Major prion protein

AP86920 1mg
EUR 2640

Major prion protein

AP87104 1mg
EUR 2640

Major prion protein

AP87394 1mg
EUR 2640

Major prion protein

AP87421 1mg
EUR 2640

Prion Protein Peptide

45-123P 0.1 mg
EUR 405.6
Description: (IN) Prion Protein (143-153) Peptide

Prion Protein particl

PrP250 2 ML
EUR 393.75

Prion Protein (PRNP) Protein

abx263341-10mg 10 mg
EUR 325

Prion Protein (PRNP) Protein

abx263341-25mg 25 mg
EUR 1600

Prion Protein (PRNP) Protein

abx263341-5mg 5 mg
EUR 225

Cluster of Differentiation 230 Prion Protein Disease Form (CD230 PrPSc) Antibody

abx414218-025mg 0.25 mg
EUR 710.4

Prion -HRP, Antibody

GWB-32B00A 0.25 ml Ask for price

Prion protein PrP (PRNP) (93-109) mouse monoclonal antibody, clone 6D11, Purified

AM05042PU-N 0.1 ml Ask for price
Jasplakinolide therapy decreases proliferation of MDA-MB-231 cells in each dose and time dependent method. Results recommend that subtoxic doses of jasplakinolide induce morphological adjustments in MDA-MB-231 cells from flat spindle form adherent cells to spherical weakly adherent types. Mechanistically, jasplakinolide therapy was discovered to lower SNTA1 protein ranges and its tyrosine phosphorylation standing. Moreover, migratory potential of jasplakinolide handled cells was considerably inhibited in comparability to regulate cells. Our outcomes display that jasplakinolide inhibits cell migration by impairing SNTA1 functioning in breast most cancers cells.

Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators

Glucocorticoid receptor (GR) is a ligand-dependent transcription issue that performs a central position in irritation. GR exercise can also be modulated by way of protein-protein interactions, together with binding of 14-3-Three proteins induced by GR phosphorylation. However, the particular phosphorylation websites on GR that set off these interactions and their practical penalties are much less clear. Hence, we sought to look at this technique in additional element. We used phosphorylated GR peptides, biophysical research and X-ray crystallography to determine key residues inside the ligand binding area of GR, T524 and S617, whose phosphorylation leads to binding of the consultant 14-3-3 protein 14-3-3ζ.

A kinase display recognized MINK1 as liable for phosphorylating T524 and ROCK1 for phosphorylating S617; cell-based approaches confirmed the significance of each GR phosphosites and MINK1 however not ROCK1 alone in inducing GR-14-3-Three binding. Together our outcomes present molecular-level perception into 14-3-3-mediated regulation of GR and spotlight each MINK1 and the GR-14-3-Three axis as potential targets for future therapeutic intervention. Tau hyperphosphorylation is a modification steadily noticed after mind ischemia which has been associated to the aggregation of this protein, with subsequent cytoskeletal harm, and mobile toxicity.

The current examine assessments the speculation of utilizing glucosamine, an agent that will increase protein O-GlcNAcylation, to lower the degrees of phosphorylation in Tau throughout ischemia-reperfusion. Transient focal ischemia was artificially induced in male Wistar rats by occlusion of the center cerebral artery (MCAO) with an intraluminal monofilament. A single dose of intraperitoneal glucosamine of 200 mg/kg diluted in regular saline (SSN) was administered 60 minutes earlier than ischemia.

Histological mind sections had been processed utilizing oblique immunofluorescence with major antibodies (anti-O-GlcNAc and anti pTau-ser 396). The Image J software program was used to calculate the immunofluorescence sign depth. The phosphorylation of Tau on the serine residue 396 had a major lower with the administration of glucosamine throughout ischemia-reperfusion in contrast with the administration of placebo. These outcomes present that glucosamine can cut back the phosphorylation ranges of Tau in rodents subjected to ischemia and cerebral reperfusion, which suggests a neuroprotective position of glucosamine.

A Phytophthora sojae CRN effector mediates phosphorylation and degradation of plant aquaporin proteins to suppress host immune signaling

Phytophthora genomes encode a myriad of Crinkler (CRN) effectors, a few of which comprise putative kinase domains. Little is understood in regards to the host targets of those kinase-domain-containing CRNs and their infection-promoting mechanisms. Here, we report the host goal and practical mechanism of a conserved kinase CRN effector named CRN78 in a infamous oomycete pathogen, Phytophthora sojae. CRN78 promotes Phytophthora capsici an infection in Nicotiana benthamiana and enhances P. sojae virulence on the host plant Glycine max by inhibiting plant H2O2 accumulation and immunity-related gene expression. Phylogenetic evaluation means that the phosphorylation websites of PIP2 proteins and the kinase domains of CRN78 homologs are extremely conserved amongst larger crops and oomycete pathogens, respectively.

Further investigation reveals that CRN78 interacts with PIP2-family aquaporin proteins together with NbPIP2;2 from N. benthamiana and GmPIP2-13 from soybean on the plant plasma membrane, and membrane localization is important for virulence of CRN78. Next, CRN78 promotes phosphorylation of NbPIP2;2 or GmPIP2-13 utilizing its kinase area in vivo, resulting in their subsequent protein degradation in a 26S-dependent pathway. Our knowledge additionally demonstrates that NbPIP2;2 acts as a H2O2 transporter to positively regulate plant immunity and reactive oxygen species (ROS) accumulation.

Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators

Xenogeneic silencing depends on temperature-dependent phosphorylation of the host H-NS protein in Shewanella

Lateral gene switch (LGT) performs a key position in shaping the genome evolution and environmental adaptation of micro organism. Xenogeneic silencing is essential to make sure the secure acquisition of LGT genes into host pre-existing regulatory networks. We beforehand discovered that the host nucleoid structuring protein (H-NS) silences prophage CP4So at heat temperatures but permits this prophage to excise at chilly temperatures in Shewanella oneidensis. However, whether or not H-NS silences different genes and the way micro organism modulate H-NS to control the expression of genes haven’t been absolutely elucidated.

In this examine, we found that the H-NS silences many LGT genes and the xenogeneic silencing of H-NS depends on a temperature-dependent phosphorylation at heat temperatures in S. oneidensis. Specifically, phosphorylation of H-NS at Ser42 is crucial for silencing the cold-inducible genes together with the excisionase of CP4So prophage, a chilly shock protein, and a stress-related chemosensory system. By distinction, nonphosphorylated H-NS derepresses the promoter exercise of those genes/operons to allow their expression at chilly temperatures. Therefore, this examine elucidates a conserved and novel pathway used by effector proteins to inhibit host mobile defenses by concentrating on and hijacking phosphorylation of plant aquaporin proteins.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) CLIA Kit

20-abx493008
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

DLR-ANGPTL3-Mu 96T
EUR 302
Description: serum, plasma, tissue homogenates or other biological fluids.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

DLR-ANGPTL3-Mu-48T 48T
EUR 445.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

DLR-ANGPTL3-Mu-96T 96T
EUR 567.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

EKN43483-48T 48T
EUR 247.73

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

EKN43483-5x96T 5x96T
EUR 1681.03

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

EKN43483-96T 96T
EUR 353.9

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

EKU02372-48T 48T
EUR 363.65

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

EKU02372-5x96T 5x96T
EUR 2467.63

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

EKU02372-96T 96T
EUR 519.5

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

DL-ANGPTL3-Mu 96T
EUR 287
Description: serum, plasma, tissue homogenates or other biological fluids.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

EK12618 96Т
EUR 768

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

abx518186-96tests 96 tests
EUR 764.4

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

abx570757-96tests 96 tests
EUR 764.4

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

20-abx153640
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

RDR-ANGPTL3-Mu-48T 48T
EUR 309.33
Description: serum, plasma, tissue homogenates and other biological fluids.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

RDR-ANGPTL3-Mu-48Tests 48 Tests
EUR 446.4

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

RDR-ANGPTL3-Mu-96T 96T
EUR 441.84
Description: serum, plasma, tissue homogenates and other biological fluids.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

RDR-ANGPTL3-Mu-96Tests 96 Tests
EUR 612

Mouse Angiopoietin Like Protein 3(ANGPTL3)ELISA kit

QY-E20091 96T
EUR 433.2

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

SEB699Mu-10x96wellstestplate 10x96-wells test plate
EUR 3549.37
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

SEB699Mu-1x48wellstestplate 1x48-wells test plate
EUR 397.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

SEB699Mu-1x96wellstestplate 1x96-wells test plate
EUR 516.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

SEB699Mu-5x96wellstestplate 5x96-wells test plate
EUR 1963.79
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

4-SEB699Mu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

RD-ANGPTL3-Mu-48T 48T
EUR 294.6
Description: serum, plasma, tissue homogenates and other biological fluids.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

RD-ANGPTL3-Mu-48Tests 48 Tests
EUR 427.2

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

RD-ANGPTL3-Mu-96T 96T
EUR 420.8
Description: serum, plasma, tissue homogenates and other biological fluids.

Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit

RD-ANGPTL3-Mu-96Tests 96 Tests
EUR 585.6

Mouse ANGPTL3(Angiopoietin Like Protein 3) ELISA Kit

ELK1328-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse ANGPTL3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse ANGPTL3. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse ANGPTL3, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse ANGPTL3 in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse ANGPTL3(Angiopoietin Like Protein 3) ELISA Kit

ELK1328-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse ANGPTL3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse ANGPTL3. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse ANGPTL3, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse ANGPTL3 in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse ANGPTL3(Angiopoietin Like Protein 3) ELISA Kit

RE2893M-48wells 48 wells
EUR 116.55

Mouse ANGPTL3(Angiopoietin Like Protein 3) ELISA Kit

RE2893M-96wells 96 wells
EUR 161.55

Mouse Angiopoietin Like Protein 1 (ANGPTL1) Protein

20-abx065326
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Angiopoietin Like Protein 2 (ANGPTL2) Protein

20-abx065332
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Angiopoietin Like Protein 4 (ANGPTL4) Protein

20-abx065337
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Angiopoietin Like Protein 6 (ANGPTL6) Protein

20-abx065341
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Angiopoietin Like Protein 7 (ANGPTL7) Protein

20-abx065342
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Angiopoietin Like Protein 8 (ANGPTL8) Protein

20-abx165988
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Angiopoietin Like Protein 3, ANGPTL3 GENLISA ELISA

KLM1107 1 x 96 wells
EUR 341

Mouse Angiopoietin Like Protein 1 ELISA kit

E03A0504-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Angiopoietin Like Protein 1 ELISA kit

E03A0504-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Angiopoietin Like Protein 1 ELISA kit

E03A0504-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Angiopoietin Like Protein 2 ELISA kit

E03A0505-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Angiopoietin Like Protein 2 ELISA kit

E03A0505-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Angiopoietin Like Protein 2 ELISA kit

E03A0505-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Angiopoietin Like Protein 4 ELISA kit

E03A0507-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Angiopoietin Like Protein 4 ELISA kit

E03A0507-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Angiopoietin Like Protein 4 ELISA kit

E03A0507-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Angiopoietin Like Protein 1 ELISA kit

E01A17712 96T
EUR 700
Description: ELISA

Mouse Angiopoietin Like Protein 2 ELISA kit

E01A17713 96T
EUR 700
Description: ELISA

Mouse Angiopoietin Like Protein 4 ELISA kit

E01A17715 96T
EUR 700
Description: ELISA

Mouse Angiopoietin Like Protein 8 ELISA kit

E01A19040 96T
EUR 700
Description: ELISA

Mouse Angiopoietin Like Protein 4 ELISA Kit

IMSANGPTL4KT each
EUR 718
Description: Mouse Angiopoietin Like Protein 4 ELISA Kit

Mouse Angiopoietin Like Protein 8 ELISA Kit

IMSANGPTL8KT each
EUR 820
Description: Mouse Angiopoietin Like Protein 8 ELISA Kit

Angiopoietin Like Protein 3 (ANGPTL3) Polyclonal Antibody (Mouse)

4-PAB699Mu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Angiopoietin Like Protein 3 (ANGPTL3)

ELISA kit for Mouse ANGPTL3 (Angiopoietin Like Protein 3)

E-EL-M2458 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse ANGPTL3 (Angiopoietin Like Protein 3) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse ANGPTL3 (Angiopoietin Like Protein 3)

ELK1328 1 plate of 96 wells
EUR 446.4
Description: A sandwich ELISA kit for detection of Angiopoietin Like Protein 3 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA

KT-32311 96 tests
EUR 977

Angiopoietin Like Protein 3 (ANGPTL3) Polyclonal Antibody (Mouse), PE

4-PAB699Mu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Angiopoietin Like Protein 3 (ANGPTL3). This antibody is labeled with PE.

Angiopoietin Like Protein 3 (ANGPTL3) Polyclonal Antibody (Mouse), APC

4-PAB699Mu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Angiopoietin Like Protein 3 (ANGPTL3). This antibody is labeled with APC.

Angiopoietin Like Protein 3 (ANGPTL3) Polyclonal Antibody (Mouse), Cy3

4-PAB699Mu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Angiopoietin Like Protein 3 (ANGPTL3). This antibody is labeled with Cy3.

Angiopoietin Like Protein 3 (ANGPTL3) Polyclonal Antibody (Mouse), FITC

4-PAB699Mu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Angiopoietin Like Protein 3 (ANGPTL3). This antibody is labeled with FITC.

Angiopoietin Like Protein 3 (ANGPTL3) Polyclonal Antibody (Mouse), HRP

4-PAB699Mu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Angiopoietin Like Protein 3 (ANGPTL3). This antibody is labeled with HRP.

Angiopoietin Like Protein 3 (ANGPTL3) Antibody

abx432327-200ul 200 ul
EUR 343.2

Angiopoietin Like Protein 3 (ANGPTL3) Antibody

20-abx301351
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Angiopoietin Like Protein 3 (ANGPTL3) Antibody

abx036974-100ug 100 ug
EUR 469.2

Angiopoietin Like Protein 3 (ANGPTL3) Antibody

20-abx129753
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  • 100 ug
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  • 1 mg
  • 200 ug
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Angiopoietin Like Protein 3 (ANGPTL3) Antibody

20-abx175387
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  • 1 mg
  • 200 ug

Angiopoietin Like Protein 3 (ANGPTL3) Antibody

20-abx171223
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  • 1 mg
  • 200 ug

Angiopoietin Like Protein 3 (ANGPTL3) Antibody

20-abx171224
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  • 1 mg
  • 200 ug

Angiopoietin Like Protein 3 (ANGPTL3) Antibody

abx230398-100ug 100 ug
EUR 610.8

Angiopoietin Like Protein 3 (ANGPTL3) Antibody

20-abx110976
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  • 150 ul
  • 50 ul

Angiopoietin Like Protein 3 (ANGPTL3) Antibody

20-abx137513
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  • 100 ug
  • 20 ug
  • 5 ug

Angiopoietin Like Protein 3 (ANGPTL3) Antibody

20-abx121014
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  • 100 ul
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  • 30 ul

Angiopoietin Like Protein 3 (ANGPTL3) Antibody

20-abx103092
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  • 100 ug
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  • 1 mg
  • 200 ug
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Angiopoietin Like Protein 3 (ANGPTL3) Antibody

20-abx103093
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  • 100 ug
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  • 1 mg
  • 200 ug
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Angiopoietin Like Protein 3 (ANGPTL3) Antibody

20-abx000824
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  • 100 ul
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  • 20 ul
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Angiopoietin Like Protein 3 (ANGPTL3) Antibody

abx032949-400ul 400 ul
EUR 627.6

Angiopoietin Like Protein 3 (ANGPTL3) Antibody

abx032949-80l 80 µl
EUR 343.2

Mouse Angiopoietin Like Protein 7 (ANGPTL7) CLIA Kit

20-abx496221
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Angiopoietin Like Protein 8 (ANGPTL8) CLIA Kit

20-abx496289
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Angiopoietin Like Protein 4 (ANGPTL4) CLIA Kit

20-abx492328
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Angiopoietin Like Protein 2 (ANGPTL2) CLIA Kit

20-abx493252
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Angiopoietin Like Protein 2 (ANGPTL2) CLIA Kit

abx195202-96tests 96 tests
EUR 990

Mouse Angiopoietin Like Protein 4 (ANGPTL4) CLIA Kit

abx195204-96tests 96 tests
EUR 990

Mouse ANGPTL2 -Angiopoietin Like Protein 2- CLIA Kit

E-CL-M0079-24Tests 24 Tests
EUR 180
Description: Sandwich

Mouse ANGPTL2 -Angiopoietin Like Protein 2- CLIA Kit

E-CL-M0079-48Tests 48 Tests
EUR 546
Description: Sandwich

Mouse ANGPTL2 -Angiopoietin Like Protein 2- CLIA Kit

E-CL-M0079-96Tests 96 Tests
EUR 682
Description: Sandwich

Mouse ANGPTL2 -Angiopoietin Like Protein 2- CLIA Kit

E-CL-M0079-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Mouse ANGPTL2 -Angiopoietin Like Protein 2- CLIA Kit

E-CL-M0079-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Mouse ANGPTL4 -Angiopoietin Like Protein 4- CLIA Kit

E-CL-M0080-24Tests 24 Tests
EUR 180
Description: Sandwich

Mouse ANGPTL4 -Angiopoietin Like Protein 4- CLIA Kit

E-CL-M0080-48Tests 48 Tests
EUR 546
Description: Sandwich

Mouse ANGPTL4 -Angiopoietin Like Protein 4- CLIA Kit

E-CL-M0080-96Tests 96 Tests
EUR 682
Description: Sandwich

Mouse ANGPTL4 -Angiopoietin Like Protein 4- CLIA Kit

E-CL-M0080-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Mouse ANGPTL4 -Angiopoietin Like Protein 4- CLIA Kit

E-CL-M0080-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

DLR-ANGPTL2-Mu 96T
EUR 454
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

DLR-ANGPTL2-Mu-48T 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 2 (ANGPTL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

DLR-ANGPTL2-Mu-96T 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 2 (ANGPTL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

DLR-ANGPTL4-Mu 96T
EUR 454
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

DLR-ANGPTL4-Mu-48T 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 4 (ANGPTL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

DLR-ANGPTL4-Mu-96T 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 4 (ANGPTL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit

DLR-ANGPTL7-Mu 96T
EUR 518
Description: serum, plasma, tissue homogenates or other biological fluids.

Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit

DLR-ANGPTL7-Mu-48T 48T
EUR 679.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 7 (ANGPTL7) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit

DLR-ANGPTL7-Mu-96T 96T
EUR 889.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 7 (ANGPTL7) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit

DLR-ANGPTL8-Mu 96T
EUR 518
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit

DLR-ANGPTL8-Mu-48T 48T
EUR 679.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 8 (ANGPTL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit

DLR-ANGPTL8-Mu-96T 96T
EUR 889.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 8 (ANGPTL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

EKN43480-48T 48T
EUR 370.02

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

EKN43480-5x96T 5x96T
EUR 2510.85

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

EKN43480-96T 96T
EUR 528.6

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

EKN43486-48T 48T
EUR 370.02

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

EKN43486-5x96T 5x96T
EUR 2510.85

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

EKN43486-96T 96T
EUR 528.6

Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit

EKN43490-48T 48T
EUR 428.05

Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit

EKN43490-5x96T 5x96T
EUR 2904.63

Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit

EKN43490-96T 96T
EUR 611.5

Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit

EKN43492-48T 48T
EUR 428.05

Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit

EKN43492-5x96T 5x96T
EUR 2904.63

Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit

EKN43492-96T 96T
EUR 611.5

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

EKU02369-48T 48T
EUR 542.78

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

EKU02369-5x96T 5x96T
EUR 3683.15

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

EKU02369-96T 96T
EUR 775.4

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

EKU02375-48T 48T
EUR 542.78

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

EKU02375-5x96T 5x96T
EUR 3683.15

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

EKU02375-96T 96T
EUR 775.4

Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit

EKU02379-48T 48T
EUR 629.02

Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit

EKU02379-5x96T 5x96T
EUR 4268.35

Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit

EKU02379-96T 96T
EUR 898.6

Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit

EKU02381-48T 48T
EUR 629.02

Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit

EKU02381-5x96T 5x96T
EUR 4268.35

Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit

EKU02381-96T 96T
EUR 898.6

Mouse Angiopoietin Like Protein 6(ANGPTL6)ELISA kit

GA-E0839MS-48T 48T
EUR 403.2

Mouse Angiopoietin Like Protein 6(ANGPTL6)ELISA kit

GA-E0839MS-96T 96T
EUR 640.8

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

DL-ANGPTL2-Mu 96T
EUR 432
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

DL-ANGPTL4-Mu 96T
EUR 432
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit

DL-ANGPTL7-Mu 96T
EUR 494
Description: serum, plasma, tissue homogenates or other biological fluids.

Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit

DL-ANGPTL8-Mu 96T
EUR 494
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

EK12615 96Т
EUR 768

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

EK12621 96Т
EUR 768

Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit

EK12625 96Т
EUR 768

Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit

EK12627 96Т
EUR 768

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

abx570701-96tests 96 tests
EUR 848.4

Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit

abx572497-96tests 96 tests
EUR 886.8

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

abx575925-96tests 96 tests
EUR 999.6

Mouse Angiopoietin Like Protein 6 (ANGPTL6) ELISA Kit

abx520387-96tests 96 tests
EUR 801.6

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

abx518830-96tests 96 tests
EUR 848.4

Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit

abx254887-96tests 96 tests
EUR 886.8

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

abx255069-96tests 96 tests
EUR 848.4

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

abx255181-96tests 96 tests
EUR 848.4

Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit

20-abx153639
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit

20-abx153641
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Taken collectively, our outcomes reveal that the posttranslational modification of H-NS can perform as a regulatory swap to manage LGT gene expression in host genomes to allow the host bacterium to react and thrive when environmental temperature adjustments. The capability to modulate direct MHC class I (MHC I) Ag presentation is a fascinating objective for the remedy of quite a lot of circumstances, together with autoimmune illnesses, persistent viral infections, and cancers. It is due to this fact obligatory to grasp how adjustments within the mobile atmosphere alter the cells’ capability to current peptides to T cells. The unfolded protein response (UPR) is a signaling pathway activated by the presence of extra unfolded proteins within the endoplasmic reticulum.

The Predicted Key Molecules, Functions, and Pathways That Bridge Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD).

To elucidate the important thing molecules, features, and pathways that bridge gentle cognitive impairment (MCI) and Alzheimer’s illness (AD), we investigated open gene expression information units.

Differential gene expression profiles have been analyzed and mixed with potential MCI- and AD-related gene expression profiles in public databases.

Then, weighted gene co-expression community evaluation was carried out to determine the gene co-expression modules. One module was considerably negatively related to MCI samples, by which gene ontology perform and Kyoto Encyclopedia of Genes and Genomes pathway enrichment evaluation confirmed that these genes have been associated to cytosolic ribosome, ribosomal construction, oxidative phosphorylation, AD, and metabolic pathway.

The different two modules correlated considerably with AD samples, by which practical and pathway enrichment evaluation revealed sturdy relationships of those genes with cytoplasmic ribosome, protein binding, AD, most cancers, and apoptosis.

In addition, we regarded the core genes within the module community intently associated to MCI and AD as bridge genes and submitted them to protein interplay community evaluation to display for main pathogenic genes in accordance with the connectivity info.

Among them, small nuclear ribonucleoprotein D2 polypeptide (SNRPD2), ribosomal protein S3a (RPS3A), S100 calcium binding protein A8 (S100A8), small nuclear ribonucleoprotein polypeptide G (SNRPG), U6 snRNA-associated Sm-like protein LSm3 (LSM3), ribosomal protein S27a (RPS27A), and ATP synthase F1 subunit gamma (ATP5C1) weren’t solely main pathogenic genes of MCI, but additionally bridge genes.

In addition, SNRPD2, RPS3A, S100A8, SNRPG, LSM3, thioredoxin (TXN), proteasome 20S subunit alpha 4 (PSMA4), annexin A1 (ANXA1), DnaJ warmth shock protein member of the family A1 (DNAJA1), and prefoldin subunit 5 (PFDN5) weren’t solely main pathogenic genes of AD, but additionally bridge genes.

Next, we screened for differentially expressed microRNAs (miRNAs) to foretell the miRNAs and transcription components associated the MCI and AD modules, respectively.

The significance rating of miRNAs in every module was calculated utilizing a hypergeometric check to acquire the miRNApivot-Module interplay pair. Thirty-four bridge regulators have been analyzed, amongst which hsa-miR-519d-3p was acknowledged because the bridge regulator between MCI and AD. Our research contributed to a greater understanding of the pathogenic mechanisms of MCI and AD, and would possibly result in the event of a brand new technique for medical analysis and remedy.

The Predicted Key Molecules, Functions, and Pathways That Bridge Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD).
The Predicted Key Molecules, Functions, and Pathways That Bridge Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD).

KRT17 Functions as a Tumor Promoter and Regulates Proliferation, Migration and Invasion in Pancreatic Cancer by way of mTOR/S6k1 Pathway.

Pancreatic most cancers (PC) is among the most well-known malignancies with excessive mortality, however the underlying mechanism of PC stays unknown. Keratin17 (KRT17) expression has been reported in lots of malignancies, however its features in PC are usually not clear.

The purpose of our research was to guage KRT17 expression and its potential function in PC.The on-line databases GEPIA and THPA have been used to determine KRT17 expression in tissues.

Quantitative real-time PCR (qRT-PCR) was used to find out KRT17 expression in cell traces. Ki67 and ROS ranges have been detected by immunofluorescence assay and a 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) probe.

KRT17 downregulation was induced by the small interfering RNA (siRNA) method. Proliferation perform was evaluated by colony formation assay and RTCA. Migration and invasion have been evaluated by transwell migration assay.

A Western blot assay was used to detect protein ranges.KRT17 was overexpressed in PC tissues in comparison with that in regular tissues. The outcomes confirmed that Ki67 and ROS ranges have been decreased in pancreatic most cancers cells after transfection with siKRT17.

After KRT17 downregulation in PC cell traces, cell viability features, together with proliferation, migration and invasion, and mTOR/S6K1 phosphorylation ranges have been attenuated.KRT17 knockdown considerably inhibited proliferation, migration and invasion in pancreatic most cancers cells.